Croscarmellose Sodium

Name: Croscarmellose Sodium

CAS No.：74811-65-7

Package: 5kg/bag, 25kg/drum

Appearance: White or off-white powder; hygroscopic. This product swells in water and

forms a suspension. It is insoluble in absolute ethanol, ether, acetone or toluene.

Quality Standard: CP2020, USP43-NF38, EP10.0

Application: 

This product is usually used as a disintegrating agent for capsules, tablets and granules.

Its water-swelling capacity is better than that of low-substituted sodium carboxymethyl cellulose and microcrystalline cellulose, and has better disintegrating effect.

In tablets, this product is suitable for direct tableting and wet granulation.

In wet granulation, internal and external processes can be used to better display the disintegration effect.

Generally the concentration of it is up to 5% (W/W) used as a disintegrating agent, the usual amount of direct tableting is about 2% (W/W), the usual amount of wet granulation is about 3% (W/W).

For hydrophobic auxiliary (such as calcium phosphate) compressed tablets, the

disintegration effect is better, the minimum 0.5% (W/W) can exert the disintegration effect.

However, when methyl cellulose is as a binder, it will prolong the disintegration time of this product. The greater the viscosity of methyl cellulose, the longer the extension time.

In addition, this product can be used for swelling materials of pulse preparations, solid dispersion carriers, gastrointestinal dwelling bioadhesive drug release systems, etc.