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Dibenzylidene acetone can be used as a ligand to prepare palladium catalysts, which are widely used in catalytic hydrogenation, coupling, carbonylation, alkyne cyclotrimerization and other aspects. For example, palladium-catalyzed Negishi reaction between halogenated hydrocarbons and organozinc, StilleChemicalbook reaction between halogenated hydrocarbons and organotin, Suzuki reaction between halogenated hydrocarbons and organoboroboron, Heck reaction between halogenated hydrocarbons and olefins, etc., such reactions have a wide range of uses in the synthesis of natural products, polymers, functional materials, liquid crystal materials, and bioactive compounds and drugs.