In This Store
Category:Active Pharmaceutical Ingredients
Product Name:Dulaglutide
CAS No.:923950-08-7
Standard:ChP, USP, BP, EP, JP, In-house Standards, IP, Ph. Int
Company:Shenzhen Tianyuan Pharmaceutical Technology Co., Ltd.
Grade: Pharmaceutical Grade
Factory Location: Zhongcheng Future Industrial Park, Hangcheng Avenue, Baoan District, Shenzhen
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Asia,Middle East,Africa
Contract Manufacturing: CRO,CMO
Sample Provided: no
Payment Terms: L/C
Description:Dulaglutide (LY2189265) is a glucagon-like peptide-1 (GLP-1) receptor agonist.
Target:GLP-1 receptor
In Vivo:Dulaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist. No specific Dulaglutide-related cause of death is identified. Survival is numerically increased for both genders of animals in all Dulaglutide treatment groups and reaches statistical significance (P≤0.05) in the 0.5- and 5-mg/kg males and in the 0.05-, 0.5-, and 1.5-mg/kg females. Mean times to peak plasma concentration values of Dulaglutide are observed at 12 hours after dosing on day 1 and rang between 12 and 48 hours at week 52. The incidence of thyroid C-cell adenoma is significantly (P≤0.05) increased compare with controls in males and females at the Dulaglutide 0.5-, 1.5-, and 5-mg/kg doses.
Animal Admin:The tumorigenic potential of Dulaglutide is evaluated in rats and transgenic mice. Rats are injected sc twice weekly for 93 weeks with Dulaglutide 0, 0.05, 0.5, 1.5, or 5 mg/kg corresponding to 0, 0.5, 7, 20, and 58 times, respectively. Transgenic mice are dosed sc twice weekly with Dulaglutide 0, 0.3, 1, or 3 mg/kg for 26 weeks.
Density:1.4±0.1 g/cm3
Molecular Formula:C149H221N37O49
Molecular Weight:3314.62
LogP:3.81
Index of Refraction:1.706
Contact Us
Tel: (+86) 400 610 1188
WhatsApp/Telegram/Wechat: +86 13621645194
+86 15021993094
Follow Us: