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Email ：PharmaSources@imsinoexpo.com
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Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Eastern Europe,Australasia,Asia,Middle East,Africa
Sample Provided: no
【 Main ingredient 】 Enrofloxacin
【 Properties 】 This product is almost colorless to light yellow clear liquid.
【 Pharmacological action 】 Pharmacodynamics Enrofloxacin is a broad spectrum bactericide for fluoroquinolone animals. It has a good effect on Escherichia coli, Salmonella, Klebsiella, Brucella, Pasteurella, actinobacillus pleuropneumoniae, Erysipelas, Proteus, Serratia marcescens, Corynebacterium pyogenes, portococcus septicus, Staphylococcus aureus, mycoplasma, chlamydia, etc. It has a weak effect on Pseudomonas aeruginosa and streptococcus, and a weak effect on anaerobic bacteria. It has obvious post-antibacterial effect on sensitive bacteria. The antibacterial mechanism of this product is to inhibit bacterial DNA rotation enzyme, interfere with bacterial DNA replication, transcription, repair and recombination, and bacteria can not grow and reproduce normally and die.
Pharmacokinetics This product is well absorbed by most animals when taken internally. The bioavailability is 62.2% to 84%, widely distributed in poultry, and can enter tissues and body fluids (including bone) well, except cerebrospinal fluid, the concentration of the drug in almost all tissues is higher than that in plasma. Liver metabolism is mainly caused by the removal of 7-piperazine ring ethyl to generate ciprofloxacin, followed by oxidation and glucuronic acid binding. It is mainly excreted by the kidneys (by renal tubule secretion and glomerular filtration), and 15% to 50% is excreted from the urine in its original form. The elimination half-life of this product in chicken is 9.1~14.2 hours.
【 Drug interaction 】
(1) This product has a synergistic effect with aminoglycoside or broad-spectrum penicillin.
(2)Ca2+, Mg2+, Fe3+, AI3+ and other heavy metal ions can chelate with this product, affecting the absorption.
(3) When combined with theophylline and caffeine, the plasma protein binding rate can be reduced due to the change of protein binding rate, the concentration of theophylline and caffeine in the blood is abnormally increased, and even the symptoms of theophylline poisoning appear.
(4) This product has the effect of inhibiting liver drug enzymes, which can reduce the clearance rate of drugs mainly metabolized in the liver, and increase the blood drug concentration.
【 Action and use 】 Quinolone antibacterial drugs. For bacterial diseases and mycoplasma infections.
[Usage and dosage] Mixed drink: 0.5~0.75ml for poultry per IL of water.
【 Adverse reaction 】
(1) Degeneration of cartilage in young animals, affecting bone development and causing lameness and pain.
(2) The reaction of the digestive system is loss of appetite, diarrhea, etc.
【 Note 】
(1) Poultry that lays eggs for human consumption shall not be used during the laying period.
(2) Black bone chicken is prohibited.
【 Drug withdrawal period 】 Poultry 8 days.
[Specification] 10%
【 Packaging 】
【 Storage 】 Dark, sealed storage.
[Approval number] Veterinary Medicine 170611298
【 Production enterprise 】 Wuhan Liyao Pharmaceutical Co., LTD
Audited Supplier
Pharma Sources Insight JANUARY 2024
