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Products

Active Pharmaceutical Ingredients

Finerenone

Category:

Active Pharmaceutical Ingredients

CAS NO:

1050477-31-0

Standard:

ChP,USP,BP,EP,JP,In-house Standards,IP,Ph. Int,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Asia,Middle East,Africa

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Shenzhen Tianyuan Pharmaceutical Technology Co., Ltd.

Years

Standard Member

Show Room

Favorites

Basic Info

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Payment Method

L/C

Samples Provided

YES

Product Description

Finerenone Biological Activity

Description:Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.

In Vivo:Finerenone (BAY 94-8862) lowers albuminuria by >40% and significantly reduces systolic blood pressure (SBP) in Munich Wistar Frömter (MWF) rat[1]. Animal Model: Twelve-week-old MWF rat[1] Dosage: 10 mg/kg Administration: P.o.; daily for 4 weeks Result: Significantly reduced SBP in MWF rats; led to a significant reduction (>40%) in albuminuria in the MWF model. Animal Model: Twelve-week-old MWF rat[1] Dosage: 10 mg/kg Administration: P.o.; daily for 4 weeks Result: Significantly reduced SBP in MWF rats; led to a significant reduction (>40%) in albuminuria in the MWF model.

Molecular Formula:C21H22N4O3

Molecular Weight:378.42400

Exact Mass:378.16900

PSA:111.25000

LogP:4.27338