Hydroxypropyl beta cyclodextrin in the anticancer drug oxaliplatin

Oxaliplatin is the first Cyclohexanediamine platinum anticancer drug to enter the market. It has the characteristics of clear anticancer effect, low toxicity, and obvious inhibition on colorectal cancer cell lines and cisplatin resistant cell lines. The combination of oxaliplatin with 5-fluorouracil and folic acid has been used as the first-line drug in the treatment of colorectal cancer, and widely used in the treatment of gastric cancer, ovarian cancer and so on. However, oxaliplatin is slightly soluble in water and has poor stability in water. It can react with water molecules to form diamine cyclohexaneplatinum dihydrate, and its aqueous solution will gradually oxidize to dihydroxyoxaliplatin in the presence of oxygen.
It is found that when hydroxypropyl betacyl dextrin is selected as the stabilizer of oxaliplatin aqueous solution, the total amount of related substances measured according to the detection method of oxaliplatin for injection in USP can not increase more than 0.25% within 24 hours after the preparation of the solution. Compared with the current oxaliplatin aqueous solution prepared according to the existing technology, it has the advantages of providing its stability. It has obvious advantages, while hydroxypropyl beta cyclodextrin, as a skeleton agent, can be used in the lyophilized preparation of oxaliplatin. The quality of the finished product, especially the related substances, is better than the products on the market.
Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. is a scientific and technological company focusing on the application, development and innovation of cyclodextrin and cyclodextrin derivatives. The company has strong technical force and close cooperation with Shandong University, Chinese Academy of Sciences and other first-class universities and scientific research institutes at home and abroad. It is a professional R & D and production enterprise with the largest variety and the most complete specifications in the cyclodextrin industry in China. Hydroxypropyl beta cyclodextrin and sulfobutyl ether beta cyclodextrin sodium salt are our two main products with complete qualification, and they have been registered on CDE, welcome to discuss.