Hygromycin B

Hygromycin B CAS Number 31282-04-9 Molecular Formula C20H37N3O13 Molecular Weight 527.52 EC Number 250-545-5 MDL number MFCD06795479 PubChem Substance ID 24895807 Package：100MG,250MG,1G,10g,100g Function: Antibiotic,antibacterial, anthelmintic Application: Antibiotic,antibacterial, anthelmintic Tags: Anti Bacterial

Hygromycin B, a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome.

Price list

Hygromycin B is an aminoglycoside antibiotic substance naturally produced by Streptomyces hygroscopicus, which also shows anthelmintic activity. Hygromycin B has been shown to effectively inhibit translocation of mRNA and tRNAs on the ribosome in both bacteria and eukaryotes and also has a subtle effect on decoding fidelity as it slightly increases aminoacyl tRNA (A-site tRNA) affinity. Suitable for the selection of cells transfected with Escherichia coli hygromycin resistance gene (hyg or hph), as well as for the maintenance of the Hygromycin phenotype of resistant cells. Consistent with its more specific effect on translocation, hygromycin B exhibits monophasic inhibition of polypeptide synthesis, suggesting that it binds to a single site on the ribosome.