ketoconazole 65277-42-1

Ketoconazole is a white crystalline powder. No smell, no taste. It is soluble in chloroform, soluble in methanol, slightly soluble in ethanol and almost insoluble in water. The melting point of this product melting point is 146 ℃. Take this product than the curl, precision said, adding methanol solution of each 1 ml contains 40 mg determination in accordance with the law, calculated on dry goods, than the curl should be 1 ° to + 1 °. The product is a pink suspension.

Density: 1.38 g/cm3

Melting point: 146 ° C

Boiling point: 753.4 C at 760 mmHg

Flash: DHS 409.4 C

Refractive index: - 10.5 ° C = 0.4, CHCl3)

Stability: under normal storage and operation conditions, it is stable at room temperature in an airtight container

Storage conditions: the warehouse is ventilated and low-temperature dry, and stored separately from food raw materials

use

Ketoconazole is an imidazole antifungal agent. The mechanism of ketoconazole is to inhibit the biosynthesis of ergosterol in fungal cell membrane, to affect the permeability of cell membrane and to inhibit its growth. Ketoconazole can be used to treat superficial and deep fungal diseases, such as skin and onychomycosis, vaginal candidiasis, gastrointestinal fungal infections, and systemic infections caused by candida albicans, coccidioides, and histoplasma