L-glycine

Glycine

Glycine is an organic compound with the formula NH2CH2COOH.

Having a hydrogen substituent as its side-chain, glycine is the smallest of the 20 amino acids commonly found in proteins. Its codons are GGU, GGC, GGA, GGG cf. the genetic code.

USage:

Possibly Effective for:

• Treating schizophrenia, when used with other conventional medicines.
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• Treating leg ulcers, when applied as a cream that also contains other amino acids.
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• Treating the most common form of stroke (ischemic stroke). Putting glycine under the tongue may help to limit brain damage caused by an ischemic stroke when started within 6 hours of having the stroke. An ischemic stoke is caused by the blockage of a blood vessel (usually by a clot) in the brain. Brain cells beyond the obstruction don’t receive oxygen and begin to die, causing irreversible damage.

Insufficient Evidence for:

• Memory enhancement.
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• Benign prostatic hypertrophy (BPH).
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• Liver protection.
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• Cancer prevention.
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• Other conditions.

More evidence is needed to rate the effectiveness of glycine for these uses.
 

GLYCINE Dosing

The following doses have been studied in scientific research:

BY MOUTH:

• For treating schizophrenia: Glycine has been used in doses ranging from 0.4 to 0.8 g/kg daily in divided doses. It is usually started at 4 g daily and increased by 4 g per day until the effective dose is reached.

UNDER THE TONGUE:

• For protecting brain cells (neuroprotection) after onset on a stroke caused by a clot (ischemic stroke): 1 to 2 g per day started within 6 hours after stroke onset.

APPLIED TO THE SKIN:

• For treating leg ulcers: A cream containing 10 mg of glycine, 2 mg of L-cysteine, and 1 mg of DL-threonine per gram of cream has been used. The cream was applied at each wound cleaning and dressing change once daily, every other day, or twice daily.