M-DMG-2000

JenKem Technology provides Methoxy PEG DMG (MPEG DMG; Methoxy PEG Dimyristoyl-rac-glycero) products with high purity and substitution (≥ 95%), in both GMP and non-GMP grade, from small lab scale through large kilogram scale. MPEG DMG products are useful for lipid nanoparticles for mRNA delivery such as those used for Covid-19 vaccine manufacture1.

Lipid Nanoparticles (LNPs) are delivery systems commonly employed in the field of nucleic acid drugs. LNPs are generally believed to combine with the cell membrane through non-covalent affinity and absorbed by endocytosis. After being absorbed by the cell, the mRNA delivered by LNPs are released to the cytoplasm and express the target protein, escaping from the endocytosis. LNP technology has been adopted for COVID-19 vaccine manufacture1.

JenKem Technology has scaled up the GMP manufacture of mPEG DMG derivatives for LNPs, such as M-DMG-2000 (Methoxy PEG Dimyristoyl-rac-glycero, MW 2000; DMG-PEG-2000; CAS 1397695-86-1), and related PEG intermediates. Please contact us for a quotation.