mPEG-C-DMG

mPEG-C-DMG is a polyethylene glycol (PEG) lipid conjugate that plays a pivotal role in the formulation of lipid nanoparticles (LNPs), particularly for drug delivery systems. The 'mPEG' prefix denotes methoxy polyethylene glycol, which is known for its ability to confer stealth properties to nanoparticles, thereby reducing their recognition and clearance by the immune system. The 'C-DMG' component refers to a dimyristoyl glycerol (DMG) lipid anchor that is carbamate-linked (C) to the PEG chain.

mPEG-C-DMG is especially significant in the development of therapeutic delivery vehicles, such as those used for mRNA vaccines, where it contributes to the efficient encapsulation of nucleic acids and their delivery to target cells. Its inclusion in LNP formulations has been crucial for the success of several modern pharmaceuticals, enhancing both the stability and efficacy of the encapsulated therapeutic agents.