Peginterferon alfa-2b

Peginterferon alfa-2b (40kD, Y-shape)

A covalent conjugate of recombinant interferon alfa-2b with a Y-shape branched polyethylene glycol (PEG) chain (approx. 40 kD).

Dosage form

Sterile, preservative-free, clear injectable solution for s.c. administration

Strength and package

• Prefilled syringe: 90μg (0.33MU) /0.5ml, 135μg (0.5MU)/0.5ml and 180μg (0.66MU)/0.5ml
• Tube vial: 180μg (0.66MU)/0.5ml

Shelf life and storage condition

36 months at 2ºC - 8ºC, protect from light

Indication

Chronic hepatitis B & C

Highlights

• Y-shape branched PEG: original and innovated structure with international patents
• Specific modification site, high antiviral activity
• Extended elimination half-life, longer dose interval
• Cytology activity significantly higher than Peginterferon alfa 2a (40kD)
• Purity (SDS-PAGE & RP-HPLC): ≥ 97%
• Bacterial endotoxins: < 2 EU/vial; [Peginterferon alfa 2a (40kD): ≤5 EU/vial]