Phenylephrine Hydrochloride

NAME

common name

盐酸去氧肾上腺素

English name

Phenylephrine  Hydrochloride

chemical name

(R)-(-)-α-[(methylamino)methyl]-3-hydroxybenzyl alcohol hydrochloride

CAS number

61-76-7

Chemical structure

Chemical Structure

.HCl

Molecular formula

C₉H₁₃NO₂.HCL

Molecular weight

203.67

Main quality standard

project

Standard limit

Traits

White or off-white crystalline powder; odorless, bitter; melting point 140 ~ 145 ° C; specific rotation should be -43 ° to -47 °

Identification

1) Take 10mg of this product, add 1ml of water to dissolve, add 1 ml of copper sulfate test solution and 1ml of sodium hydroxide test solution, shake it, it will be purple; add 1ml of ether to shake, the ether layer should not color. (2) Take 10mg of this product, add 1ml of water to dissolve, add 1 drop of ferric chloride test solution, which is purple. (3) Identification of the chloride in the aqueous solution of this product (Appendix III). (4) The infrared absorption spectrum of this product should be consistent with the control spectrum (spectrum set 819).

Examination pH

4.5-5.5

Solution clarity and color

Take this product 0. 20g, add water 10. O m l to dissolve, the solution should be clear and colorless

Sulfate

≤0.20%

Loss on drying

≤1.0%

Residue on ignition

≤0.2%

relative substance

Norphenylephrine≤0.10%， Phenylephrine related compound C≤0.1%，Phenylephrine related compound D≤0.10%，Phenylephrine related compound E≤0.1%,Any individual unspecified impurity≤0.10%,Total impurities≤0.2%

content

98.5%~102.0%