Smatostatin for Injection

Note: the content below do not include all the information needed to use Somatostatin for Injection safely and effectively. Please read the package insert carefully and follow the doctors’ instructions before use the product.

INDICATIONS AND USAGE

It is indicated for：

1. Severe acute esophageal variceal bleeding.
2. Severe acute gastric or duodenal ulcer bleeding, or acute erosive gastritis or hemorrhagic gastritis.
3. Auxiliary treatment of pancreatic, biliary and intestinal fistula.
4. Prevention and treatment of complications after pancreatic surgery.
5. Auxiliary treatment of diabetic ketoacidosis.

DOSAGE AND ADMINISTRATION

Intravenous administration:

Dissolve with normal saline before use, inject 0.25mg/3~5min with slow impact, or continuously drip 0.25 mg/h (equivalent to 3.5 μ g / kg · h according to body weight). When the interval between infusion and administration is more than 3~5min, the measure of reinjection 0.25 mg of this product should be taken to ensure the continuity of administration.

Treatment of severe acute gastrointestinal bleeding (including esophageal variceal bleeding):

It is suggested that 0.25 mg somatostatin should be injected into the vein slowly as the loading dose, and then 0.25mg/h intravenous drip should be given immediately. When the interval between the two infusion is more than 3~5min, the measure of intravenous injection of 0.25 mg somatostatin should be taken again to ensure the continuity of administration. When the bleeding is stopped (usually within 12~24 hours), the treatment should be continued for 48~72 hours to prevent further bleeding. For these cases, the usual treatment time is 120 hours.

Auxiliary treatment of pancreatic fistula, biliary fistula and intestinal fistula:

Intravenous drip should be used at a rate of 0.25mg/h until the fistula is closed (2~20 days). This treatment can be used as an auxiliary measure of total parenteral nutrition. When the fistula is closed, the intravenous drip of somatostatin should be continued for 1-3 days, and then the drug should be stopped gradually to prevent rebound.

Prevention and treatment of complications after pancreatic surgery:

At the beginning of the operation, somatostatin is used as adjuvant treatment; intravenous drip is 0.25mg/h. After the operation, the intravenous drip lasts for 5 days.

Adjuvant treatment of diabetic ketoacidosis:

Continuous intravenous drip at the rate of 0.1~0.5mg/h is used as an auxiliary measure for insulin treatment (1-4.8u/h intravenous drip after 10u shock). Generally in 3 hours to alleviate ketoacidosis, 4 hours can make blood sugar return to normal.

DOSAGE FORMS AND STRENGTHS

Lyophilized powder: 3.0 mg