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Tirzepatide has a similar sequence to semaglutide, and the lys side chain in the sequence is PEG-modified, which is a functional group of the polypeptide and can increase the water solubility of the sequence. TirzepaChemicalbooktide main physiological function is glucose-dependent insulin nutritional polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor dual agonist, which is being developed for the treatment of type 2 diabetes and has entered the clinical stage.