TRIMETHOPRIM(TMP)

Trimethoprim (TMP) 

Source & Properties:

• Synthetic antibacterial medication belonging to the folate antagonist class.
• White to faintly yellowish, crystalline powder with slight solubility in water.

Mechanism of Action:

• Inhibits bacterial dihydrofolate reductase, an enzyme crucial for bacterial folate synthesis.
• Folate deficiency disrupts bacterial growth and reproduction.

Pharmaceutical Applications:

• Prescription medication only: Not available for direct sale.
• Primarily used in combination with sulfamethoxazole (co-trimoxazole) for treating various bacterial infections:
  • Urinary tract infections.
  • Respiratory tract infections (pneumonia, bronchitis).
  • Traveler's diarrhea.
  • Certain parasitic infections.