Vinpocetine

Vinpocetine is a cerebrovascular dilator, which has a stronger effect than vinpocetine and selectively increases cerebral blood flow. It can enhance and improve the oxygen supply of the brain, promote metabolism, enhance the deformability of red blood cells, reduce blood viscosity, inhibit platelet aggregation, and improve the metabolism of brain tissue. Mainly used to treat cerebral infarction sequelae, cerebral hemorrhage sequelae, cerebral arteriosclerosis and so on. It is also used to treat retinal vascular sclerosis and vasospasm, deafness and vertigo in the elderly. Vinpocetine is a semi-synthetic vinpocetine derivative. The effect is similar to that of vincamine, which has a high selective dilation effect on cerebral vessels. Pharmacological effects are as follows: ① Inhibition of calcium-dependent phosphodiesterase activity increases cAMP content in relaxed vascular smooth muscle, thereby relaxing vascular smooth muscle and increasing cerebral blood flow. ② Enhance red blood cell deformability, reduce blood viscosity, inhibit platelet aggregation, thereby improving blood mobility and microcirculation. ③ Promote the uptake of glucose in brain tissue and promote the metabolic transformation of monoamine in brain. ④ During cerebral ischemia, it can inhibit the increase of lactic acid in the brain, increase the content of ATP, inhibit the production of lipid peroxide in the brain, delay the occurrence time of cerebral ischemia spasm, so it has the effect of improving brain metabolism and protecting brain function.