Innovative Liposomal Vitamin C by West Bengal Chemical Industries Ltd., Kolkata, India: Enhancing Nu

Citation: Innovative Liposomal Vitamin C by West Bengal Chemical Industries Ltd., Kolkata, India: Enhancing Nutraceutical Effectiveness. (2025). Eastern Journal of Medical Sciences, 10(2). https://doi.org/10.32677/ejms.v10i2.7302

Abstract: Objective: To evaluate the physicochemical properties, stability, and absorption behavior of a liposomal Vitamin C formulation developed by West Bengal Chemical Industries Ltd. (WBCIL) using non-genetically modified sunflower-derived phosphatidylcholine, with a focus on its potential as a topical alternative to conventional Vitamin C supplements. Methods: The liposomal formulation was synthesized and subjected to comprehensive characterization using advanced analytical techniques. High-Performance Liquid Chromatography (HPLC) was used to determine encapsulation efficiency. Fourier Transform Infrared Spectroscopy (FTIR) was employed to identify functional groups, while X-Ray Photoelectron Spectroscopy (XPS) confirmed elemental composition. Dynamic Light Scattering (DLS) was used to measure hydrodynamic particle size, zeta potential, and polydispersity index. Stability and sustained release of Vitamin C were evaluated under physiological and thermal conditions. Results: The formulation demonstrated a high encapsulation efficiency of 91.98%, with an average particle size of 184 nm. The zeta potential was -33.7 mV, indicating excellent electrostatic stability, while the polydispersity index (PDI) of 0.334 reflected uniform particle distribution. FTIR confirmed the presence of functional groups associated with Vitamin C and phosphatidylcholine, and XPS analysis detected the target elements on the surface of the liposomal Vitamin C. The formulation exhibited sustained release properties and maintained structural integrity under various conditions, suggesting good thermal and physiological stability. Conclusion: WBCIL’s liposomal Vitamin C formulation offers high encapsulation efficiency, nanoscale size, and excellent stability, making it a promising and bioavailable alternative to traditional Vitamin C supplements. Its potential for topical application enhances its value for skin health, particularly in promoting collagen synthesis and photoprotection.