Mallinckrodt, Silence Therapeutics Enter RNAi Alliance

Silence Theraputics and Mallinckrodthave entered a collaboration to develop and commercialize RNAi drug targets designed to inhibit or ‘silence’ the complement cascade, a group of proteins that are involved in the immune system and that play a role in the development of inflammation.
 
The agreement provides Mallinckrodt with an exclusive worldwide license for C3 (SLN500) - a preclinical asset that targets a specific protein in the complement pathway - and an option for up to two additional assets with different complement protein targets.
 
Under the agreement, Mallinckrodt will make an upfront payment of $20 million. Silence is also eligible to receive up to $10 million in research milestones for SLN500 and for each optioned asset, in addition to funding for Phase I clinical development including GMP manufacturing.
 
"We are very excited by the significant potential offered by Silence's RNAi technology to meet the needs of underserved patients in a number of serious and critical conditions, and we look forward to collaborating with them to advance development of complement-targeted assets as new therapeutic options," said Steven Romano, M.D., Chief Scientific Officer and Executive Vice President of Mallinckrodt.
 
"This collaboration combines Silence Therapeutics' knowledge and world-class research and development in the field of RNAi with Mallinckrodt's expertise and resources as a global biopharmaceutical company with years of experience solving complex challenges," said Dr. David Horn Solomon, President and Chief Executive Officer of Silence Therapeutics. "The increasing number of clinical conditions and pathologies that involve the complement system has generated significant interest in the development of therapeutic options to inhibit complement activation, which holds great promise in treating a range of diseases. We look forward to working closely with Mallinckrodt to extend our capabilities with RNAi therapies that have the potential to transform patients' lives."  

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