CStone Pharmaceuticals ("CStone" or the "Company", HKEX: 2616) today announced that the Company has recently received the approval from the Human Research Ethics Committee (HREC) in Australia, and the acknowledgement from Australia's Therapeutic Goods Administration (TGA) on the Phase I clinical trial of CS3005. This Phase I trial is an open-label, multicenter, dose-escalation study designed to evaluate the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of CS3005 in patients with advanced solid tumors.
The tumor microenvironment (TME) is a cellular space in which the tumor dynamically interacts with the surrounding blood vessels, immune cells, stromal components, signaling molecules, and the extracellular matrix. Studies showed that multiple compensatory immunosuppressive mechanisms exist in the TME not only contribute to the development of tumors but also affect the response to immunotherapies. The adenosine signaling pathway plays a critical role in immune modulation and is an important compensatory resistance mechanism against immune checkpoint inhibitors.
Discovered by CStone, CS3005 is an adenosine A2a receptor antagonist that modulates the tumor immune microenvironment. CS3005 could potentially activate antitumor immunity and improve the response to immune checkpoint inhibitors by blocking the binding of adenosine with adenosine A2a receptors and thereby reversing the immunosuppressive mechanism. At present, no adenosine A2a receptor antagonist has been approved for cancer treatment anywhere in the world.
"I am pleased that the clinical trial of CS3005 has been approved in Australia. This drug candidate is the Company's first tumor immune microenvironment modulator entering clinical development as we have begun to roll out CStone's Pipeline 2.0," said Dr. Frank Jiang, Chairman and CEO of CStone. "Immuno-oncology therapy has brought new hope to cancer patients in recent years, yet many patients fail to respond to those treatments. We are hopeful that the research and development of tumor microenvironment modulators will allow immunotherapies to benefit more patients."
CStone's Chief Scientific Officer, Dr. Jon Wang, noted: "Early studies on adenosine A2a receptor antagonists have shown good safety profiles and antitumor activities, either as monotherapies or in combination with immune checkpoint inhibitors, in patients with advanced solid tumors. Interestingly, adenosine A2a receptor antagonists have also demonstrated antitumor activities in patients with low PD-L1 expressing tumors or who are resistant/refractory to anti-PD-(L)1. These observations implicate possible benefits to patients with solid tumors. CS3005 also adds to the depth and flexibility of CStone's strategy in immuno-oncology combination therapy."
About CS3005
CS3005 is a highly selective adenosine A2a receptor antagonist discovered by CStone.
Immunotherapy has achieved great success in the treatment of advanced tumors, but response to therapy remains suboptimal due to the existence of multiple compensatory immunosuppressive mechanisms in the tumor microenvironment (TME). Among those mechanisms, the adenosine signaling pathway plays a key role in down-regulating anticancer immunity. Hypoxia in the TME results in strained energy supply to tumor cells and cell death, and the subsequent release of a large amount of adenosine triphosphate (ATP) into the TME. ATP is then metabolized into adenosine by CD39 and CD73, thereby causing the accumulation of extracellular adenosine in the TME. The level of adenosine in the TME is much higher than that in normal tissues. Upon binding with adenosine A2a receptors, adenosine suppresses the innate and adaptive immune function of immune cells. The adenosine A2a receptor is expressed in a host of immune cells such as the T-cells, natural killer (NK) cells, monocytes, and dendritic cells. Early clinical studies of adenosine A2a receptor antagonists, as monotherapies or in combination with immune checkpoint inhibitors, have shown good safety profiles and antitumor activities in patients with advanced tumors, including those with low PD-L1 expressing tumors or who are resistant/refractory to anti-PD-(L)1. These observations implicate potentially broad clinical applications of adenosine A2a receptor antagonists to the treatment of solid tumors and in immuno-oncology combination therapies.
About CStone
CStone Pharmaceuticals (HKEX:2616) is a biopharmaceutical company focused on developing and commercializing innovative immuno-oncology and precision medicines to address the unmet medical needs of cancer patients in China and worldwide. Established in 2015, CStone has assembled a world-class management team with extensive experience in innovative drug development, clinical research, and commercialization. The company has built an oncology-focused pipeline of 15 drug candidates with a strategic emphasis on immuno-oncology combination therapies. Currently, 5 late-stage candidates are at pivotal trials. With an experienced team, a rich pipeline, a robust clinical development-driven business model and substantial funding, CStone's vision is to become globally recognized as a leading Chinese biopharmaceutical company by bringing innovative oncology therapies to cancer patients worldwide.
Forward-looking Statement
The forward-looking statements made in this article relate only to the events or information as of the date on which the statements are made in this article. Except as required by law, we undertake no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise, after the date on which the statements are made or to reflect the occurrence of unanticipated events. You should read this article completely and with the understanding that our actual future results or performance may be materially different from what we expect. In this article, statements of, or references to, our intentions or those of any of our Directors or our Company are made as of the date of this article. Any of these intentions may alter in light of future development.
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