Top Bulk Griseofulvin Powder Manufacturers in China Recommended

Description of Griseofulvin Powder

Griseofulvin Powder is an antifungal drug that treats several dermatophytoses. It can work best where other antifungal creams do not work. The powder can help to treat fungal infections on the scalp and nails. Generally, the description of griseofulvin powder focuses on skin and hair microsized infections.

What is Griseofulvin Used For?

Griseofulvin powder can treat minor or trivial skin infections like ringworm of the skin, athlete’s foot, and jock itch. It is the best treatment for ringworm skin infections since it comes with trivial-infections safety features. In any case, it is an FDA-approved drug available for fungistatic diseases and controlling fungi that cause tinea, toenails, fingernails, and the scalp.

Nevertheless, it would be best to advise the patient about using the drugs rightly to make sure that it remains specifically active against superficial skin. The drug will take up to a year to clear up nail infection and about two weeks to clear hair or skin infection.

Griseofulvin vs Terbinafine

In general, a six to eight weeks dose of griseofulvin powder is as effective as two to four weeks doses of terbinafine when you use it to treat Trichophyton infections on the scalp. Powder griseofulvin is superior to terbinafine in treating fungi that cause tinea.

It would be best to opt for griseofulvin powder as an antifungal treatment specifically active against superficial fungi that cause tinea.

Griseofulvin Specifications and Forms

Its molecular formula is C17H17ClO6, and the molar mass is 352.766 g·mol−1. The drug falls under the antifungal agent category, which comprises other medications that can work the same way. These medications work by binding to the surface of the fungal infection causing body part.

Hence, griseofulvin powder microsize can also help to inhibit ferrochelatase activity. Its activities help to insert iron into the porphyrin ring. In other words, it impedes porphyrin metabolism to trigger acute porphyria attacks and can also control ringworm in horses.

On the other hand, oral griseofulvin tablets feature 250mg and 500mg. It also exists as a 99% white powder or griseofulvin cream for the skin surface. The two griseofulvin forms are suitable for oral suspension. However, the 99% griseofulvin ultramicrosize powder can work better.

Griseofulvin Mechanism of Action

Its oral therapy can inhibit mitosis since it binds to the tubulin to impede microtubule functions. It gets attached to the keratin in the cells to make them resistant to fungal conditions. Above all, it will get to the infected part when the skin or hair gets replaced with the keratin-griseofulvin complex.

The drug will penetrate the dermatophyte via an energy-dependent procedure. Next, it will bind to the fungal microtubules. This step will then alter the mitosis process and the underlying space for fungal cell wall deposition. Hence, veterinary can use it to treat infections that cause tinea ringworm.

Griseofulvin Manufacturing Process

Its industrial production involves penicillium griseofulvum fermentation. The initial step in the drugs’ biosynthesis process is the 14-carbon poly-β-keto chain synthesis. The first step consists of type I iterative PKS (polyketide synthase) through a 6 malonyl-CoA interactive addition to an acyl-CoA starter unit.

The next step would be the aromatization or cyclization of the 14-carbon poly-β-keto chain. This step uses a small amount of feed aromatase or cyclase, respectively. Next, it passes through aldol and Claisen condensation to create the benzophenone intermediate. Ultimately, the procedure involves methylation of the benzophenone intermediate through SAM (S-adenosyl methionine) two times to produce griseophenone C.

The griseophenone C gets halogenated at the site ortho to produce griseophenone B. Next, the procedure would be to undertake the halogenated species through a phenolic oxidation process to create two oxygen-diradical species. Finally, a stereoselective olefin reduction helps to form griseofulvin.

Griseofulvin Side Effects

Common adverse effects include feeling tired, trouble sleeping, headache, diarrhea, nausea, and allergic reactions. Therefore, the drug is not suitable for people with porphyria or liver failure. Also, using it during pregnancy can harm the baby.

Griseofulvin Dose

It would be best to ensure that the patient strictly follows the instructions they received at the pharmacy. For instance, an adult should take a dose of about 500mg to 1000mg per day. In other words, the amount must be more than 10mg per KG body weight daily. It would be best to administer it as a single daily drug.

Where To Buy Griseofulvin Bulk Powder?

Finding the best place to purchase griseofulvin powder in bulk is crucial for your pharmaceutical business. Thus, it would be best to mention that supplying your customers with the wrong medicine could result in hazardous side effects. For that reason, you must find a certified and reliable vendor to provide you with bulk griseofulvin powder.

Luckily, PharmaSources invest in offering bulk griseofulvin powder. If you want to order medical supplies online, then PharmaSource might be your best choice. They have developed a reliable platform for providing beneficial info about pharmaceutical products and suppliers for worldwide buyers. The platform has served over 90,000 pharmaceutical buyers worldwide from more than 211 different regions.

They also offer more than 1,600,000 products that belong to about 30 other pharma supply chains. In any case, this platform can be the best place if you need to buy bulk griseofulvin at an affordable rate. Their prices are manageable, and the delivery service is unbeatable.

FAQ:

What’s the price for bulk griseofulvin?

The most common form of griseofulvin is GoodRx, and its price is about $50 for the micro size. This value is about 73% off the average price for retail ($189). The drug is primarily available in 2.5 grams griseofulvin tablets, and the price may vary from one pharmacy to another.

How long does it take for griseofulvin to work?

A recent meta-analysis found that the drug is an orally effective tinea capitis therapy. Experts say that the most effective dosage is 20 to 25 mg per kg daily for about four to six weeks. The drug will take a few weeks to clear up hair and skin infection, but it may take longer for nail infection.