List of Mupirocin Calcium Bulk powder Manufacturers from China

What Is Mupirocin?

Mupirocin, previously termed pseudomonic acid A, is a novel prescription medication belonging to the class of drugs called topical antibiotics. 

This product is mainly used to treat skin infections, especially impetigo. It may also be helpful to combat methicillin-resistant S. aureus (MRSA) when present in the nose without symptoms.

As Mupirocin is unrelated in the mode of action and chemical structure to any known class of antibacterial medications, it does not have cross-resistance with them. While it is mainly used as a topical agent, it is also available for intranasal use.

Definition

Mupirocin is a natural crotonic acid derivative extracted from Pseudomonas fluorescens. 

ChEBI defines it as “An alpha,beta-unsaturated ester resulting from the formal condensation of the alcoholic hydroxy group of 9-hydroxynonanoic acid with the carboxy group of (2E)-4-[(2S)-tetrahydro-2 -pyran-2-yl]-3-methylbut-2-enoic acid in which the tetrahydropyranyl ring is substituted at positions 3 and 4 by hydroxy groups and at position 5 by a {(2S,3S)-3-[(2S,3S)-3-hydro ybutan-2-yl]oxiran-2-yl}methyl group. Originally isolated from the Gram-negative bacterium Pseudomonas fluorescens, it is used as a topical antibiotic for the treatment of Gram-positive bacterial infections.”

Cas Number

12650-69-0

Molecular Formula

C26H44O9

Chemical Structure

It has a unique chemical structure consisting of a short fatty acid side chain linked via an ester bond to monic acid.

Chemical Properties

This product is obtained from the crystallized ether. Its melting point is 77~78 ℃. [α]D20-19.3°(C = 1, methanol). The maximum absorption of UV (ethanol): 222nm(ε14500).

Mupirocin Base Vs Mupirocin Calcium

Mupirocin Base or simply Mupirocin contains Mupirocin 2% in a water-miscible polyethylene glycol base. It is also the parent compound of Mupirocin Calcium. 

IUPAC Name of Mupirocin: 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid

On the other hand, Mupirocin Calcium is the calcium salt form of Mupirocin. It contains the dihydrate crystalline calcium hemi-salt Mupirocin 2% w/w equivalent to 20 mg Mupirocin as the active ingredient.

IUPAC Name of Mupirocin Calcium: calcium;9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoate;dihydrate

Mechanism of Action of Mupirocin

Mupirocin reversely combines with isoleucine transfer RNA synthetase, preventing the isoleucine incorporation. This inhibits protein synthesis in cells with isoleucine, an enzyme required by bacteria to produce proteins. As bacteria cannot make proteins, they die.

Due to this unique action, Mupirocin does not have cross-resistance with other classes of antimicrobial agents. It has an extensive and rapid metabolism and is thus available as topical formulatio

Mupirocin is bacteriostatic at lower concentrations. However, this product offers bactericidal effects with prolonged exposure, destroying 90-99% of susceptible bacteria within 24 hours.

It works well in fighting staphylococci and most streptococci. But offers lesser protection against other gram-positive and gram-negative bacteria.  The rate of occurrence is significantly low in vitro resistant mutants.

Its action on Staph. Aureus is influenced by inoculum so that a 10-fold increase in the inoculum doubles the minimum inhibitory concentration (MIC) in vitro. Mupirocin activity also reduces when pH increases above the normal skin pH of 5.5. Its action is prominent in acidic medium.

Synthesis of Mupirocin

Mupirocin is a metabolic substance produced in vitro in the culture solution of pseudomonas fluorescence (Pseudomonas A). It contains 0.5-5% of Mupirocin, 60-89% of polyethylene glycol 400, 10-36% of polyethylene glycol 4000, and 0.04-0.4 % of organic acid.

It is synthesized in the following steps:

• Initially, the organic acid is dissolved in obtains mixture in the PEG400 

• Macrogol 4000 is again added to the said mixture, 

• The above combination is heated to 50-60 ℃ to melt Macrogol 4000 melting

• The mixture is stirred

• Mupirocin is added to the above mixture and stirred under 50-60 ℃ condition to dissolve it

Mupirocin Forms and Specifications

There are various Mupirocin specifications available, including:

• Mupirocin 2% USP

• Mupirocin Ointment

• Mupirocin Cream

• Mupirocin Powder

What Is Mupirocin Used For (Mupirocin Ointment Uses)

Mupirocin is an antibacterial agent that is effective against a wide range of gram-positive bacteria, especially most strains of S. aureus and Streptococcus pyogenes.

Due to its action, Mupirocin is used for the topical treatment of the following primary and secondary bacterial skin infections:

• Impetigo (school sores)

• Furunculosis (boils)

• Folliculitis

• Ecthyma

It is also effective for infected dermatoses such as eczema, atopic dermatitis, psoriasis, ichthyosis, and epidermolysis bullosa.

Mupirocin can be helpful in infected traumatic lesions such as minor burns, wounds, ulcers, abrasions, and cuts.

It is also effective in treating infections caused by meticillin-resistant Staphylococcus aureus (MRSA). This infection mainly occurs in people who are unwell and in the hospital. MRSA infection is a challenging infection to treat, and one can also pass this infection to others.

A nasal ointment with Mupirocin is available for people who have come in contact with MSRA infected patients. Mupirocin nasal ointment kills the bacteria in your nose, which can spread to others when you sneeze. It thus aids in preventing the spread of infection to others.

It may be used for other conditions purposes not listed above.

Mupirocin Side Effects

The use of Mupirocin is usually well tolerated. Allergic reaction to this product is also unknown.

However, as with other medications, it may have some side effects in some cases. A mild stinging or burning may occur after the use of this medicine. 

In rare cases, it may cause a severe intestinal condition (Clostridium difficile-associated diarrhea).

Mupirocin should be used with caution in large open wounds, especially in people with kidney disorders. 

Where to Buy Bulk Mupirocin?

You can buy Mupirocin from PharmaSources.com. It is a vertical e-commerce online destination with many quality global suppliers. PharmaSources offers high-quality products to about 211 countries and regions. PharmaSources provides pharmacy lab instruments, pharmaceutical water systems and pharmaceutical ingredients for customers. Actually, we offers more that that. If you are interested in pharmacy, you could contact with us.

FAQ

What Bacteria Does Mupirocin Kill?

Some bacteria Mupirocin can commonly kill include:

• Staphylococci aureus

• Staphylococcus saprophyticus

• Staphylococcus epidermidis

• Meticillin-resistant Staphylococcus aureus (MRSA)

• Streptococci pyogens

• Streptococcus agalactiae

• Streptococcus viridans

• Haemophilus influenzae

• Neisseria gonorrhoeae

• Streptococcus pneumoniae

Is Mupirocin the Same As Neosporin?

The short answer is a NO. While they both are topical antibiotics, Neosporin is mainly used as a first-aid antibiotic to prevent infections in minor scrapes, cuts, or burns on your skin. Neosporin is available as an over-the-counter medicine.

On the other hand, Mupirocin can kill a larger variety of bacteria. It is available as a prescription medicine and is mainly used for treating impetigo. 

References

https://pubchem.ncbi.nlm.nih.gov/compound/Mupirocin#section=Related-Compounds-with-Annotation

https://pubmed.ncbi.nlm.nih.gov/3146455/

https://go.drugbank.com/drugs/DB00410

https://au.gsk.com/media/223642/bactroban_cream_ointment_pi_004_approved.pdf

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-4362.1988.tb00936.x?sid=nlm%3Apubmed