Kanamycin sulfate uses, specifications and bulk API Manufacturers in China

What is kanamycin sulfate?

Kanamycin is an aminoglycoside antibiotic that can help treat different bacterial infections, but it is not a first-line treatment for any specific infection. It is taken as an oral, intravenous, or intramuscular injection. 

The drug was first isolated from the bacterium streptomyces kanamyceticus in 1957, and the drug is no longer marketed in the USA. It belongs to the aminoglycosides family and works by inhibiting the protein synthesis of bacteria. The most prominent side effects include kidney and hearing problems.

Physical & Chemical Features

Molecular weight: 582.6 g/mol

Molecular formula: C 18 H 38 N 4 O 15 S

CAS number: 25389-94-0

Formula weight: 582.58

Melting point: 250°C

Storage temperature: 2-8°C

Shipping: Ambient

Powder color: White to off-white

Spectrum of activity: gram-positive bacteria, gram-negative bacteria, mycobacteria, and mycoplasma

kanamycin sulfate toxicity

Kanamycin, related to other aminoglycosides, affects the vestibular and auditory branches of the eighth cranial nerve, which is responsible for hearing and balance. Consequently, Kanamycin can lead to ototoxicity manifested by vertigo and an inability to discriminate high-frequency sounds.

Moreover, aminoglycoside drugs can lead to acute renal impairment due to the effect of Kanamycin on the renal tubule. Specifically, this causes intrinsic renal failure manifested by elevated serum creatinine. 

kanamycin sulfate heat stability

Kanamycin solution is stable at 37 °C for almost five days, and it can be stored at 2-8°C for long-term storage.

Decomposition temperature of kanamycin sulfate

Kanamycin sulfate is added to the agar plate, and this plate should be sealed. This will prevent the evaporation of moisture from the agar. 

This sealed agar plate should be stored at a temperature of 2-8°C for 1 month. If the plate is not sealed well, this may lead to the evaporation of moisture and, consequently, kanamycin degradation. 

Forms and specifications

Kanamycin Sulfate Injection

Sulfate kanamycin products are administered by different routes. An injection is a common one. The drug can be given intravenously or intramuscularly. The optimum dosage is calculated based on the pretreatment body weight. Please check renal function before administration, as this can help determine the related dosage.

For intramuscular injection, it is injected in the upper outer quadrant of the gluteal muscle. The dose used (in children and adults) is 15 mg/kg/day divided equally into two doses. 

For intravenous injection, the dose used can't exceed 15 mg/kg/day, and it has to be given slowly. 

Kanamycin sulfate monohydrate

Kanamycin sulfate monohydrate is a different compound from kanamycin sulfate. It has a different molecular weight and chemical formula. Specifically, its molecular weight is 502.5 g/mol, and its formula is C18H38N4O12. The monohydrate form is usually an odorless, white crystalline powder.

kanamycin sulfate mechanism of action

The biological mechanism of action of this drug is inhibiting protein synthesis activity in bacteria. Kanamycin binds to the 30S subunit of the bacterial ribosome available. 

This leads to problems with the alignment of the mRNA and the formation of the amino acid chain in the incorrect order. Eventually, this will lead to misreading and nonfunctional proteins. 

Because bacteria may need protein to reproduce, this may lead to bacterial death.

kanamycin sulfate uses

kanamycin sulfate for fish

Kanamycin is a wide spectrum antibiotic that can treat the different gram-negative and gram-positive infections. Also, it is safe to use in scaleless fish. It can help in Fin and Tail Rot disease, a common condition of aquarium fish caused by bacteria.

Moreover, it can help treat other diseases like popeye, dropsy, and septicemia. Furthermore, the antibiotic can be absorbed by fish so that it can treat internal infections.

kanamycin spectrum of activity

Kanamycin can help in different short-term bacterial infections caused by the following organisms:

Acinetobacter 

Serratia Marcescens

Klebsiella pneumoniae

Enterobacter aerogenes

Proteus species

E. coli

kanamycin sulfate concentration in lb broth

Lb broth refers to lysogeny broth. LB is a media-rich in nutrients used in order to help culture bacteria. 

LB broth plus antibiotic information:

• The kanamycin concentration used is 50 mg/ml in H2O.

• The final concentration for growing plasmids for LB liquid culture is 50ug/ml

kanamycin sulfate powder storage

Kanamycin solution is stable at 37°C for approximately 5 days, and its aqueous stock solutions are stored at 2-8°C for long-term storage.

Where to buy bulk kanamycin sulfate?

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FAQ

is there an antagonist for kanamycin sulfate?

In real life, no kanamycin antagonist can help in cases of kanamycin toxicity.

Nevertheless, some available research information states that the effect of Kanamycin can be antagonized by liquoid (sodium polyanetholsulfonate). However, please note that these are still research data in vitro and don't have any clinical implications. 

We need more research data to help antagonize kanamycin toxic effects.

How long is Kanamycin stable?

Kanamycin sulfate is added to the agar plate, and this plate should be sealed. This will prevent the evaporation of moisture from the agar. 

This sealed agar plate should be stored at a temperature of 2-8°C for 1 month. If the plate is not sealed well, this may lead to the evaporation of moisture and, consequently, kanamycin degradation.