Where can you find the price of Tetracycline Hydrochloride API Powder and buy it in bulk?

What is Tetracycline Hydrochloride?

Tetracycline hydrochloride is a bacteriostatic, broad-spectrum antibiotic effective against an array of gram-positive and gram-negative bacteria. It belongs to the tetracycline class of antibiotics. Common brand names include Sumycin, Tetracyn, and Achromycin. 

Tetracycline Hydrochloride Forms and Specifications

Tetracycline hydrochloride is available in several different forms and specifications including tetracycline hydrochloride base powder, tetracycline hydrochloride API powder, tetracycline hydrochloride cream and ointment, and tetracycline hydrochloride capsules.  

Tetracycline Base Powder

Tetracycline hydrochloride base is available as a powder. 

Tetracycline Hydrochloride API Powder

Tetracycline hydrochloride is the salt from of tetracycline. Raw material of tetracycline hydrochloride API (CAS number 64-75-5) is in the form of a yellow crystalline powder. The specification from Chinese manufacturers Ningxia Qiyuan Pharmaceutical Co., Ltd., Fujian Fukang Pharmaceutical Co., Ltd., C&J International ChemPharm Co., Ltd., and Hebei Shengmei Medical Technology Co., Ltd. is 99% min.

Tetracycline Hydrochloride Cream and Ointment

Tetracycline hydrochloride is available in a topical cream and an ointment. The cream is used to treat skin infections. The ointment is used to treat skin or eye infections.

Tetracycline Hydrochloride Capsules

Tetracycline hydrochloride capsules are available in 250 mg and 500 mg strengths.

Tetracycline VS Doxycycline 

Tetracycline hydrochloride and doxycycline are both part of the same class of antibiotics - the tetracyclines. Although they are part of the same class, they do have some differences. 

The usual dose of tetracycline hydrochloride is 250 mg – 500 mg orally every 6 hours –12 hours, whereas doxycycline is usually 100 mg – 200 mg orally once or twice daily.  

Tetracycline hydrochloride is generally taken on an empty stomach, but doxycycline may be taken with food if stomach upset occurs. 

Mechanism of Action of Tetracycline Hydrochloride

Tetracycline hydrochloride is primarily bacteriostatic. According to (PubChem) and (Drug Bank,) Tetracycline hydrochloride inhibits protein synthesis and bacterial cell growth by binding to the 30S ribosomal subunit in the microorganism, blocking the amino-acyl tRNA from binding to the A site of the mRNA-ribosome complex. 

Tetracycline Hydrochloride Manufacturing Process

The manufacturing processes of tetracycline hydrochloride API must be completed under proper quality control systems that comply with the regulations of international Good Manufacturing Practice (GMP) in order to ensure that the API is safe and high-quality. 

Tetracycline hydrochloride is made by the fermentation of the bacterium, Streptomyces aureofaciens, followed by a chemical reaction where the dimethyl amino group protonates and produces the salt form of tetracycline in hydrochloric acid solutions. Impurities are then removed from the active ingredient by crystallization, centrifugation, drying, filtration, milling, and/or sieving. Tetracycline hydrochloride is tested and purified in compliance with quality standards until it reaches 99% min purity.

Uses of Tetracycline Hydrochloride

Tetracycline hydrochloride is used for the treatment of a variety of gram-negative and gram-positive bacteria. It is also used to treat urinary tract infections and acne.

Tetracycline Hydrochloride Dosage

The dosage for adults is usually 250 mg – 500 mg orally every 6 hours – 12 hours. The dosage for children older than 8 years of age is usually 25 mg – 50 mg/kg orally per day in divided doses every 6 hours. 

Side Effects of Tetracycline Hydrochloride

Common side effects of tetracycline hydrochloride include nausea, vomiting, diarrhea, headache, dizziness, decreased appetite, photosensitivity, discoloration of the teeth, skin rash, and tinnitus. 

Where can you find the price of Tetracycline Hydrochloride API Powder and buy it in bulk?

Below are some manufacturers in China who make active pharma ingredients.

Tetracycline Hydrochloride API Manufacturers in China:

Chinese manufacturers Ningxia Qiyuan Pharmaceutical Co., Ltd., Fujian Fukang Pharmaceutical Co., Ltd., C&J International ChemPharm Co., Ltd., and Hebei Shengmei Medical Technology Co., Ltd manufacture bulk quantities of raw material of tetracycline hydrochloride API powder 99%. If you need a price quote and certificate of analysis (COA) or a detailed specification sheet, please visit these professional and experienced manufacturers on www.pharmasources.com.  

Ningxia Qiyuan Pharmaceutical Co., Ltd.

Established in 1956, Ningxia Qiyuan Pharmaceutical Co., Ltd. has delivered pharmaceutical services for over 60 years. They are now the leading biopharmaceutical company in China, specializing in research, development, manufacturing, and marketing of active pharmaceutical ingredients (APIs), intermediates, and vitamins. 

Fujian Fukang Pharmaceutical Co., Ltd.

First established in 1958 as Fuzhou First Antibiotic Factory, the factory was re-established in 2002 as a private company, Fujian Fukang Pharmaceutical Co., Ltd. Fujian Fukang Pharmaceutical Co., Ltd. is located uniquely in the chemical and pharmaceutical industry zone. They are partnered with about 150 companies in over 35 nations and regions, some being the top pharmaceutical companies in the world. They have been awarded Chinese Good Manufacturing Practice (GMP) certification for antibiotic APIs and cephalosporin dosage forms. They are also CEP certified from EDMQ, EU GMP certified by German Health authorities, and GMP inspected by Japan PMDA. In addition, they have passed US FDA inspections. Their mission is to serve their clients with the safest and highest-quality products. For more information, visit Fujian Fukang Pharmaceutical Co., Ltd. on pharmasources.com.

C&J International ChemPharm Co., Ltd.

C&J International ChemPharm Co. Ltd. has over 10 years of experience in the pharm and chemical fields. They effectively serve clients with professionalism and skill, having become a successful link between China and the world. For more information, visit C&J International ChemPharm Co., Ltd. on pharmasources.com.

Hebei Shengmei Medical Technology Co., Ltd.

As a leading Chinese pharmaceutical wholesaler, Hebei Shengmei Medical Technology Co., Ltd. professionally manufactures and distributes APIs and vet drugs. Their main goal is to supply competitively priced products and drugs that treat deadly conditions in Africa, Asia, the Middle East, South America, etc. For more information, visit Hebei Shengmei Medical Technology Co., Ltd. on pharmasources.com.

Advantages of PharmaSources

Pharmasources.com is a professional pharmaceutical platform, dedicated to providing the highest-quality products and suppliers for their global customers. They deliver services to 900,000+ active members across 211 countries and regions, while featuring more than 1,600,000 products in 30 major categories that span the entire pharma supply chain. Their mission is “to connect global buyers with quality suppliers and facilitate easy trade of the pharmaceutical industry” (PharmaSources).

FAQ

What is the market size of tetracycline hydrochloride?

• (According to Reports Express,) the global market size of tetracycline hydrochloride was $9.5 billion in 2019 and is expected to grow at a compound annual growth rate of 8.1% through 2025.

What bacteria does tetracycline treat?

• Tetracycline hydrochloride is used for the treatment of a variety of gram-negative and gram-positive bacteria. It is also used to treat urinary tract infections and acne.

Is tetracycline a penicillin?

• No, tetracycline hydrochloride belongs to the tetracycline class of antibiotics. Tetracyclines are bacteriostatic, whereas penicillins are bactericidal.  

References:

1. About Us. SinoMedical, Hebei Shengmei Medical Technology Co., Ltd. http://www.sinomedical

.cc/about-us/. Accessed May 26, 2021. 

2. Cheprasov, Artem. Doxycycline vs. Tetracycline. Study.com. https://study.com/academy/lesson/

doxycycline-vs-tetracycline.html. Updated March 11, 2021. Accessed May 26, 2021.

3. Company Profile of C&J International ChemPharm Co., Ltd. PharmaSources. https://www.pharm

asources.com/company-profile/cj-international-chempharm-co-ltd-userId-5049.html. Accessed May 26, 2021.

4. Company Profile of Fujian Fukang Pharmaceutical Co., Ltd. PharmaSources. https://www.pharm

asources.com/company-profile/fujian-fukang-pharmaceutical-co-ltd-userId-155.html. Accessed May 26, 2021.

5. Company Profile of Ningxia Qiyuan Pharmaceutical Co., Ltd. PharmaSources. https://www.phar

masources.com/company-profile/ningxia-qiyuan-pharmaceutical-co-ltd-userId-212.html. Accessed May 26, 2021.

6. Cunha, John P., DO, FACOEP. Doxycycline vs, Tetracycline. MedicineNet. https://www.medicine

net.com/doxycycline_vs_tetracycline/article.htm#what_is_the_difference_between_doxycycline_and_tetracycline. Accessed May 26, 2021.

7. Global Tetracycline Hydrochloride Market Report 2020. Reports Express. https://reportsexpress.

com/tetracycline-hydrochloride-market-report/. Published September 29, 2020. Accessed May 26, 2021.

8. National Center for Biotechnology Information. "PubChem Compound Summary for CID 54704426, Tetracycline hydrochloride” PubChem, https://pubchem.ncbi.nlm.nih.gov/ 

compound/Tetracycline-HCl. Accessed 26 May, 2021.

9. Tetracycline. Chemical Book. https://www.chemicalbook.com/ChemicalProductProperty_

EN_CB6153810.htm#:~:text=Tetracycline%20%7C%2060%2D54%2D8. Accessed May 26, 2021.

10. Tetracycline. DrugBank. https://go.drugbank.com/drugs/DB00759. Updated May 25, 2021. Accessed May 26, 2021.

11. Tetracycline. GoodRx. https://www.goodrx.com/tetracycline. Accessed May 26, 2021.

12. Tetracycline Hydrochloride or Tetracycline HCl CAS 64-75-5. FengChen Group Co., Ltd.https://www.fengchengroup.com/pharmaceutical-api/functional-api/tetracycline-hydrochloride-or-tetracycline.html#:~:text=TetracyclineHydrochloride%2CTetracyclineHclPowderAPI%2CRaw

tetracycline.html#:~:text=TetracyclineHydrochloride%2C%20TetracyclineHclPowdmaterialsthe,sub%2Dunitsblockingproteinsynthesis. Accessed May 26, 2021.

13. Tetracyclines. GlobalRPh. https://globalrph.com/infectious-disease-list/tetracyclines/#

tetracycline-achromycin. Accessed May 26, 2021.