Where can you find the price of Minocycline Hydrochloride API Powder and buy it in bulk?

What is Minocycline Hydrochloride?

Minocycline hydrochloride is a bacteriostatic, broad-spectrum antibiotic that belongs to the tetracycline class. It is effective against a wide range of gram-positive and gram-negative bacteria. Common brand names include Minocin and Solodyn.

Minocycline Hydrochloride Forms and Specifications

Minocycline hydrochloride is available in several different forms and specifications including minocycline hydrochloride API powder, minocycline hydrochloride extended-release tablets, and minocycline hydrochloride capsules.

Minocycline Hydrochloride API Powder

Minocycline hydrochloride is the salt from of minocycline. Raw material of minocycline hydrochloride API (CAS number 13614-98-7) is in the form of a light yellow crystalline powder. The specification from Chinese manufacturers Hubei Widely Chemical Technology Co., Ltd., Zhejiang Medicine Co., Ltd., Taizhou Dachen Pharmaceutical Co., Ltd., along with SUANFARMA Group, is 99% min.

Minocycline Hydrochloride Extended-Release Tablets

Minocycline hydrochloride extended-release tablets are available in 45 mg, 55 mg, 65 mg, 80 mg, 90 mg, 105 mg, 115 mg, and 135 mg strengths.

Minocycline Hydrochloride Capsules

Minocycline hydrochloride capsules are available as generic or the brand name, Minocin. They are supplied in 50 mg, 75 mg, and 100 mg strengths.

Minocycline VS Doxycycline 

Minocycline hydrochloride and doxycycline belong to the same class of antibiotics - the tetracyclines. Although they are part of the same class, they do have some differences. 

Minocycline hydrochloride is available as oral extended-release tablets and immediate-release capsules. Doxycycline has two salt forms—hyclate and monohydrate, and is available in immediate-release tablets, immediate-release capsules, solution for injection, and a powder for oral suspension. 

The standard adult dose of minocycline hydrochloride starts with an initial 200 mg dose followed by 100 mg every 12 hours, whereas doxycycline is usually 100 mg – 200 mg orally once or twice daily. 

Mechanism of Action of Minocycline Hydrochloride

Minocycline hydrochloride is primarily bacteriostatic. According to (DrugBank,) minocycline hydrochloride inhibits bacterial protein synthesis and cell growth by binding to the 30S ribosomal subunit in the microorganism, preventing the amino-acyl tRNA from binding to the mRNA-ribosomal complex. 

Minocycline Hydrochloride Manufacturing Process

The manufacturing process of minocycline hydrochloride API is performed under proper quality control systems that comply with the regulations of international Good Manufacturing Practice (GMP) to provide safe and high-quality API.  

Minocycline undergoes a chemical reaction where the dimethyl amino group protonates, producing the salt form of minocycline, minocycline hydrochloride, from hydrochloric acid solutions. Impurities are then extracted from the active ingredient by crystallization, centrifugation, drying, filtration, milling, and/or sieving. Minocycline hydrochloride is thoroughly purified and tested in accordance with quality standards until it achieves 99% min purity.

Uses of Minocycline Hydrochloride

Minocycline hydrochloride is used for the treatment of a variety of gram-negative and gram-positive bacteria. It is also used to treat acne, tooth infections, strep throat, and rashes. 

It is also used “off label” to treat heartworms and tick-borne infections in dogs.

Minocycline Hydrochloride Dosage

The dosage for adults generally starts with an initial 200 mg dose, followed by 100 mg every 12 hours. The dosage for children older than 8 years of age is generally an initial 4 mg/kg dose, followed by 2 mg/kg/dose every 12 hours.

Side Effects of Minocycline Hydrochloride

Common side effects of minocycline hydrochloride include nausea, vomiting, and diarrhea. 

Where can you find the price of Minocycline Hydrochloride API Powder and buy it in bulk?

There are many API manufacturing companies on Pharmasources.

Minocycline Hydrochloride API Manufacturers in China:

Chinese manufacturers Hubei Widely Chemical Technology Co., Ltd., Zhejiang Medicine Co., Ltd., Taizhou Dachen Pharmaceutical Co., Ltd., along with SUANFARMA Group, manufacture bulk quantities of raw material of minocycline hydrochloride API powder 99%. If you need a price quote and certificate of analysis (COA) or a detailed specification sheet, please visit these professional and experienced manufacturers on www.pharmasources.com.  

Hubei Widely Chemical Technology Co., Ltd.

Established in 2012, Hubei Widely Chemical Technology Co., Ltd. is a high-efficient, modernized private business specializing in research, development, pharmaceutical raw materials and intermediates, fine chemical, veterinary raw materials, production and sales of plant extract, and other advanced products. They provide expert services to domestic and international clients, focusing on solidarity, excellence, continuous improvement, and mutual development. For more information, visit Hubei Widely Chemical Technology Co., Ltd. at www.pharmasources.com.

Zhejiang Medicine Co., Ltd.

Established in 1997, Zhejiang Medicine Co., Ltd. has provided manufacturing services globally for over 20 years. They manufacture and supply a variety of pharmaceutical products including APIs, intermediates, and human and animal nutritional products. Committed to providing care and high-quality products, Zhejiang Medicine Co., Ltd. operates upon occupational safety, hygiene, and environmental protection management systems in compliance with ISO 14001 and OHSAS18001. For more information, visit Zhejiang Medicine Co., Ltd. at www.pharmasources.com.

Taizhou Dachen Pharmaceutical Co., Ltd.

Established in 1969, Taizhou Dachen Pharmaceutical Co., Ltd. has been providing pharmaceutical services for over 50 years. Located in Linhai Coastal Industrial Zone of Zhejiang Provincial Chemical Raw Material Medicine Production Base, the company is scientifically and technologically designed to facilitate high-quality research and manufacturing of APIs and intermediates. They provide high-quality services at home and internationally. Their goal is to create health that is based on good faith, innovation, advancement, and cooperation. For more information, visit Taizhou Dachen Pharmaceutical Co., Ltd. at www.pharmasources.com.  

SUANFARMA Group

SUANFARMA Group was established in Spain in 1993. They specialize in the development, manufacturing, and sales of pharmaceutical, veterinary medicine, and nutritional ingredients. During the past 5 years, SUANFARMA Group expanded its company to Portugal, Colombia, and Italy. They have over 650 representatives in more than 70 countries. For more information, visit SUANFARMA Group at www.pharmasources.com. 

Advantages of PharmaSources

Pharmasources.com is a professional pharmaceutical platform, dedicated to providing information about the highest-quality products and suppliers to their global customers. They deliver services to 900,000+ active members across 211 countries and regions, while featuring more than 1,600,000 products in 30 major categories that span the entire pharma supply chain. Their mission is “to connect global buyers with quality suppliers and facilitate easy trade of the pharmaceutical industry” (PharmaSources).

FAQ

What is the half-life of minocycline?

• According to (DrugBank,) the half-life of minocycline ranges from 11.1 to 22.1 hours.

How long does minocycline stay in your system?

• Minocycline hydrochloride can remain in your body for 2.5 days to 5 days.

How long does it take minocycline to work?

• If you are taking minocycline for bacterial infections, you should start to see an improvement within a few days. However, the medication should be taken as prescribed. If you stop taking this medication too soon, your symptoms may come back.

If you are using minocycline for the treatment of acne, it may take 2 weeks to start seeing an improvement and 12 weeks to see the full benefit.

References:

1. Company Profile of Hubei widely chemical technology Co., Ltd. PharmaSources. 

http://www.pharmasources.com/company-profile/hubei-widely-chemical-technology-co-ltd-userId-69099.html. Accessed June 1, 2021. 

2. Company Profile of SUANFARMA Group. PharmaSources. 

https://www.pharmasources.com/company-profile/suanfarma-group-userId-27822.html. Accessed June 1, 2021.

3. Company Profile of Taizhou Dachen Pharmaceutical Co., Ltd. PharmaSources. 

http://www.pharmasources.com/company-profile/taizhou-dachen-pharmaceutical-co-ltd-userId-326.html. Accessed June 1, 2021.

4. Company Profile of Zhejiang Medicine Co., Ltd. PharmaSources. 

https://www.pharmasources.com/company-profile/zhejiang-medicine-co-ltd-userId-16655.html

5. Gollakner, Rania, BS, DVM, MPH. Minocycline. VCA Hospitals. https://vcahospitals.com/know-your-pet/minocycline. Accessed June 1, 2021.

6. Minocycline. GoodRx. https://www.goodrx.com/minocycline. Accessed June 1, 2021.

7. Minocycline hydrochloride. Chemical Book. 

http://m.chemicalbook.com/ProductChemicalPropertiesCB6472139_EN.htm. Accessed June 1, 2021. 

8. Minocycline hydrochloride. DrugBank. 

https://go.drugbank.com/salts/DBSALT000721. Published June 13, 2005. Updated June 1, 2021. Accessed June 1, 2021. 

9. National Center for Biotechnology Information. "PubChem Compound Summary for CID 54685925, Minocycline hydrochloride” PubChem, https://pubchem.ncbi.nlm.nih.gov/compound/Minocycline-hydrochloride. Accessed 1 June, 2021.

10. Tetracyclines. GlobalRPh. https://globalrph.com/infectious-disease-list/tetracyclines/. Accessed June 1, 2021.

11. Torres, Kristi C., Pharm.D. Minocycline vs doxycycline: Differences, similarities, and which is better for you. The Checkup by SingleCare. 

https://www.singlecare.com/blog/minocycline-vs-doxycycline/. Published July 21, 2020. Accessed June 1, 2020.