Levofloxacin API Price and Manufacturers in China

1.What is Levofloxacin?

Definition:

Levofloxacin is a third-generation antibiotic with a broad spectrum of action that is used to treat several bacterial infections, including nosocomial pneumonia, community-acquired pneumonia, acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis, acute bacterial prostatitis, acute pyelonephritis, urinary tract infections, and skin or skin structure infections.

Because of its improved activity against gram-positive bacteria commonly found in respiratory infections, levofloxacin is referred to as a "respiratory quinolone."

Levofloxacin is also used to treat people who have been exposed to anthrax or the plague.

Levofloxacin is a safe and effective medicine on the World Health Organization's list of essential medicines, and the FDA approved it for the first time in 1996.

This drug belongs to a class of drugs known as fluoroquinolone antibiotics, which work by stopping the growth of bacteria.

Levofloxacin can be used alone or in combination with other drugs, and it is available in the form of oral tablets, solutions, and intravenous administration.

Chemical & Physical properties:

Chemical structure:

Synonyms: L-Ofloxacin, (S)-Ofloxacin

Molecular weight: 361.4

Molecular formula: C18H20FN3O4

CAS number: 100986-85-4

IUPAC name: (2S)-7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid

DrugBank accession number: DB01137

Powder Color: Light yellowish-white to yellow-white crystalline powder

Melting point: 225-227 °C 

Water solubility: Sparingly soluble

Elimination half-life: 6-8 hours

Antimicrobial Spectrum: 

• Gram-positive bacteria: methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), Streptococcus pneumoniae, Listeria monocytogenes

• Gram-negative bacteria:  Enterobacteriaceae, H. influenzae, other Haemophilus spp., N. gonorrhoeae, N. meningitides, M. catarrhalis, P. aeruginosa, Stenotrophomonas maltophilia, S. maltophilia

• Atypicals:  Legionella pneumophilia

Brand names: Levaquin®, Quinsair®

2.Levofloxacin Mechanism of action

Levofloxacin belongs to the fluoroquinolone class of antibiotics, which exerts antimicrobial activity by directly inhibiting DNA synthesis in bacteria.

Levofloxacin inhibits two important bacterial enzymes: DNA gyrase and topoisomerase IV (both Type II topoisomerases), which are required for DNA replication, RNA transcription, repair, and bacterial DNA repair.

3. Levofloxacin forms and specifications

• Levofloxacin API powder

Place of Origin: Shaanxi, China

Brand Name: Accenturebio

Product Name: Levofloxacin API powder

Manufacturing Process: Chemical Synthesis

CAS Number: 100986-85-4

Price: $47-$57 per kilogram

Packaging Details: 1-25kg bag, 25kg drum

Contact Details: +8618402999820 

• Levofloxacin Hemihydrate API powder

Place of Origin: India

Company Name: Rich Pharmachem

Product Name: Levofloxacin Hemihydrate API powder

API Form: Powder

Shelf life: 4 years

Packaging Details: 25 Kg

Phone number: +91-8048884569

• Levofloxacin Lactate API powder

Place of Origin: China

Manufacturer: FENGCHEN GROUP CO., LTD.

Product Details: Levofloxacin lactate API powder

Packaging Details: 25 Kgs

CAS Number: 294662-18-3

Molecular Formula: C21H26FN3O7

Fengchen Group is a leading China supplier and manufacturer of Levofloxacin Lactate API Powder. 

Levofloxacin lactate is a prescription drug used to treat quinolone allergies, epilepsy, and acute to chronic respiratory tract infections, urinary tract infections, and skin infections.

• Levofloxacin Lactate Injection

Company Name: Shijiazhuang No. 4 Pharmaceutical Co., Ltd

Product Name: Levofloxacin Lactate Injection

Pharmaceutical Technology: Chemical Synthesis

Type: Generic Medicine

Status: Liquid

• Levofloxacin Hydrochloride Injection

Levofloxacin injection is an antibiotic that belongs to the fluoroquinolone class and works by killing bacteria that cause infections.

Levofloxacin hydrochloride injection is used to treat bacterial infections such as chronic bacterial prostatitis, complicated urinary tract infections, acute bacterial sinusitis, and skin infections.

Levofloxacin hydrochloride injection is given as a liquid solution through a vein using a needle or catheter and slowly intravenously injected for 60 to 90 minutes, every twenty-four hours.

• Levofloxacin Hydrochloride Tablets 500 mg and 750 mg

Levofloxacin tablets are used to treat various bacterial infections, including skin infections, chronic bacterial prostatitis, complicated urinary tract infections, and acute bacterial sinusitis.

Levofloxacin Tablets come in 250 mg, 500 mg, and 750 mg strengths and are available as film-coated tablets for oral administration every 24 hours with or without food.

4.Levofloxacin vs Ciprofloxacin 

Both levofloxacin (Levaquin®) and ciprofloxacin (Cipro®) are fluoroquinolone antibiotic drugs used to treat various infections caused by bacteria, including skin infections, respiratory tract infections, urinary tract infections, and chronic prostatitis.

Ciprofloxacin is a second-generation fluoroquinolone antibiotic that the FDA approved in 1987.

Ciprofloxacin is commonly used to treat mild-to-moderate respiratory and urinary tract infections, but it also treats gonorrhea, infectious diarrhea, and anthrax.

5.Levofloxacin uses

• levofloxacin for urinary tract infections (UTIs)

Levofloxacin is used to treat complicated and uncomplicated urinary tract bacterial infections caused by Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. 

• levofloxacin for ear bacterial infections

The broad-spectrum antibiotic levofloxacin is used to treat bacterial ear infections such as acute otitis media.

• levofloxacin for pneumonia

Levofloxacin is used to treat nosocomial pneumonia and community-acquired pneumonia caused by methicillin-susceptible Staphylococcus aureus, Pseudomonas aeruginosa, Serratia marcescens, Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, or Streptococcus pneumoniae. 

The recommended adult dosage is 500-750 mg every 24 hours for 7-14 days. 

6.Levofloxacin dosage

The following is the recommended levofloxacin dosage for an adult with normal renal function (creatinine clearance ≥ 50 mL/min):

• Nosocomial pneumonia: 750 mg every 24 hours for 7-14 days. 

• Community-acquired pneumonia: 500 mg every 24 hours for 7-14 days or 750 mg every 24 hours for 5 days.

• Acute bacterial sinusitis: 500 mg every 24 hours for 10-14 days or 750 mg every 24 hours for 5 days.

• Acute bacterial exacerbation of chronic bronchitis: 500 mg every 24 hours for 7 days.

• Complicated skin and skin structure infections (SSSI): 750 mg every 24 hours for 7-14 days.

• Uncomplicated SSSI: 500 mg every 24 hours for 7-10 days.

• Chronic bacterial prostatitis: 500 mg every 24 hours for 28 days.

• Complicated urinary tract infection or acute pyelonephritis: 750 mg every 24 hours for 5 days.

• Uncomplicated urinary tract infection: 250 mg every 24 hours for 3 days.

• Inhalational anthrax (post-exposure) in adults and pediatric patients > 50 kg and ≥ 6 months of age: 500 mg every 24 hours for 60 days.

7.Levofloxacin side effects

Side effects of levofloxacin include nausea, vomiting, diarrhea, headache, photosensitivity, tendinitis or tendon rupture, and peripheral neuropathy.

8.Levofloxacin manufacturing process

Levofloxacin is synthesized by reacting (S)-(-)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid with N-methyl piperazine in a polar solvent or a neat mixture to form levofloxacin.

Levofloxacin Tablets contain the following inactive ingredients: crospovidone, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, synthetic red iron oxide, and titanium dioxide.

9.Levofloxacin Active Pharmaceutical Ingredient (API) price

The average price is 48.4 (USD/KGs)

10.Levofloxacin Active Pharmaceutical Ingredients (APIs) manufacturers in china

Below are some manufacturers who are professional in making active pharma ingredients.

Zhejiang East-Asia Pharmaceutical Co., Ltd.

The company is a leading supplier which produces a wide range of quality active pharmaceutical ingredients (APIs) and intermediates.

They have established modern research and development centers. Many of the company's products have received new CGMP certification and certification from the European Union (EDQM) and the Japanese Ministry of Welfare (PMDA).

The company has long-standing relationships with customers in Europe and the United States, Asia, and more than ten countries and regions. Its product sales network spans more than 50 countries and regions.

Business Type: Manufacturer, exporter, and supplier.

Category: Active Pharmaceutical Ingredients, Antibiotics

Product Name: Levofloxacin API 

CAS Number: 100986-85-4

Contact Number: (Phone) +86-576-84088699, (Fax) +86-576-89185671

Main Sales Market: North America, South America, Europe, Australia, Asia (e.g., India), Middle East (e.g., Saudi Arabia), and Africa.

• Zhejiang Langhua Pharmaceutical Co., Ltd

It is one of the leading manufacturers and suppliers of high-quality pharmaceuticals products in China, including APIs, pharmaceutical intermediates, and preparations. 

Many prestigious multinational pharmaceutical companies have accepted the company, and it has grown to become the most valuable and innovative API supplier.

Business Type: Manufacturer, exporter, and supplier. 

Category: Active Pharmaceutical Ingredients, Antibiotics

Product Name: Levofloxacin API 

CAS Number: 100986-85-4

Standard: ChP, USP, BP, EP, JP, In-house Standards

Packaging Details: 25kg/drum

Price(USD): Negotiable 

Contact Details: (Phone number) +86-574-87260242, (Fax number) +86-574-87684590, Email- Mobile number (+86-13586505263- jason@langhuapharma.com).

Main Sales Market: America, Europe, Australia, Asia (e.g., India), and Africa.

• JIANGXI DADI PHARMACEUTICAL CO., LTD

It is one of China's top companies and suppliers, specializing in producing medicine materials, intermediates, and APIs. Their products have a good international reputation and are exported to several countries, including India and the United States.

Business Type: Manufacturer, exporter, and supplier. 

Category: Active Pharmaceutical Ingredients

Product Name: Levofloxacin API 

CAS Number: 100986-85-4

Standard: USP, In-house Standards

Contact Details: (Phone number) +86-576-87730617, (Fax number) +86-0799-7215187, Email- Mobile number (+86-0799-7215278/ sales1@dadipharm.com), (Location) Jiangxi, China.

Main Sales Market: America, Europe (Italy), Australia, Asia (Japan, India, and South Korea), Middle East (Saudi Arabia), and Africa.

Nanjing Hicin Pharmaceutical Co., Ltd

The company is located in Nanjing Economical Technological Development Zone and specialized in producing pharmaceutical preparations, synthetic APIs, and manufacturing synthetic chemicals.

They perform effective analyses and monitor pharmaceutical raw materials, intermediates, and finished products (both preparations and APIs).

Category: Active Pharmaceutical Ingredients

Financing Status: Formerly PE-Backed

Product Name: Levofloxacin API 

CAS (Chemical Abstracts Service) Number: 100986-85-4

Contact Details: (Phone number) +86-25-83222911, (Fax number) +86-86-25-83222911, (Location) Nanjing Jiangsu, China.

• Afine Chemicals Limited

AFINE CHEMICALS LIMITED is a major supplier of fine chemicals, pharmaceutical raw materials, intermediates, and feed additives based in Hangzhou, China, with a consistent national and international market, including Europe, the United States, North America, Japan, Korea, Taiwan, China, and Hong Kong, S.A.R., China.

Category: Active Pharmaceutical Ingredients, Other Anti-Infective Drug

Product Name: Levofloxacin API

CAS (Chemical Abstracts Service) Number.: 100986-85-4

Standard: ChP, USP, BP, EP, JP, In-house Standards

Contact Details: (Phone number) +86-25-83222911, (Fax number) +86-86-25-83222911, (Location) Hangzhou, Zhejiang, China.

• NINGBO NUOBAI PHARMACEUTICAL CO., LTD.

Ningbo Nuobai Pharmaceutical Co., Ltd. is committed to healthcare and focuses on pharmaceuticals-related business, including intermediates, active pharmaceutical ingredients, preparation, and technical, regulatory support.

Category: Active Pharmaceutical Ingredients

Product Name: Levofloxacin API

CAS No.: 100986-85-4

Standard: ChP, USP, BP, EP, JP, In-house Standards

Price(USD): Negotiable

Contact Details: (Phone number) +86-574-87260242 , (Fax number) +86-574-87262630, (Location) Ningbo, China.

11.FAQ

What is the market size of Levofloxacin?

The global levofloxacin market is expected to reach $1.9 billion by 2025, growing at a CAGR of 4.7 percent between 2020 and 2025.

North America, South America, Europe, and the Asia-Pacific (e.g., China, Japan, Korea) account for most of the Levofloxacin market.

The Asia-Pacific market is expected to grow at the fastest rate in terms of revenue between 2020 and 2025, owing to a significant expansion in manufacturing pharmacies.

Is Levofloxacin penicillin?

Levofloxacin is a broad-spectrum antibiotic that belongs to the fluoroquinolone class of antibiotics, not penicillin's class.

Fluoroquinolones are antibiotics that prevent bacteria from reproducing and repairing their DNA, and they are used to treat bacterial infections.

How fast does Levofloxacin work?

Because levofloxacin is rapidly and completely absorbed after oral administration, it will start working within hours, reaching a peak plasma concentration in one to two hours.

References:

1. https://pubchem.ncbi.nlm.nih.gov/compound/Levofloxacin

2. https://go.drugbank.com/drugs/DB01137

3. https://www.fda.gov/files/drugs/published/Levaquin-Label.pdf

4. https://www.rxlist.com/levaquin-drug.htm

5. https://www.drugs.com/mtm/levofloxacin.html

6. https://www.ncbi.nlm.nih.gov/books/NBK545180/

7. http://www.antimicrobe.org/drugpopup/levofloxacin.htm

8. https://www.nmn-powder.com/sale-12212496-cas-100986-85-4-top-quality-api-bactericidal-antibiotics-levofloxacin-powder-for-dogs.html

9. https://www.indiamart.com/proddetail/levofloxacin-hemihydrate-powder-22488574091.html

10. https://www.fengchengroup.com/pharmaceutical-api/antibiotics/levofloxacin-lactate-or-lavofloxacin-lactate.html

11. https://medlineplus.gov/druginfo/meds/a601154.html

12. https://m.made-in-china.com/product/Levofloxacin-Lactate-and-Sodium-Chloride-Injection-Manufacturer-852845205.html

13. https://www.drugwatch.com/cipro-levaquin-avelox/

14. https://www.pharmacompass.com/price/levofloxacin

15. https://patentimages.storage.googleapis.com/3e/40/a4/c411760ba5ed00/EP1451194B2.pdf

16. https://www.industryarc.com/Research/Levofloxacin-Market-Research-501909

17. https://www.pharmasources.com/