Paracetamol: Features, Uses, Side Effects, and API Price

Paracetamol, also known as acetaminophen, is one of the most commonly used over-the-counter pain-relieving drugs worldwide. It is a white, crystalline powder with a bitter taste and is soluble in water. In this article, we’ll look at the chemical and physical features of paracetamol, its forms and specifications, mechanism of action, use and health benefits, potential side effects, API price, and manufacturers in China.

Chemical and Physical Features of Paracetamol

Paracetamol is a synthetic compound and belongs to the family of analgesics and antipyretics. Its chemical name is N-(4-hydroxyphenyl) acetamide and its molecular formula is C8H9NO2. The melting point of paracetamol is 169-171 °C, and its pH range is 5.5-6.5. Paracetamol has a low molecular weight of 151.16 g/mol and a small therapeutic index with a moderate toxicity level.

Forms and Specifications of Paracetamol

Paracetamol is available in different forms, including tablets, capsules, oral suspension, suppositories, and intravenous injections. The tablet form of paracetamol is the most common and is available in doses ranging from 500 mg to 1000 mg. The maximum daily dose is 4000 mg. It should be noted that different forms of paracetamol may have different shelf lives and storage conditions, depending on their formulations.

Mechanism of Action of Paracetamol

Paracetamol works primarily by inhibiting the synthesis of prostaglandins in the brain and spinal cord. This mechanism of action makes it an effective painkiller and antipyretic, but it does not have any significant anti-inflammatory effects. Paracetamol is rapidly absorbed after oral administration and is metabolized mostly in the liver. The drug is excreted by the kidneys and undergoes first-order pharmacokinetics.

Use and Health Benefits of Paracetamol

Paracetamol is used mainly for the management of mild to moderate pain and fever in adults and children. It is generally considered safe and effective for the treatment of a wide variety of conditions, including headaches, toothaches, menstrual cramps, arthritis, and cold and flu symptoms. Paracetamol is also safe to use during pregnancy and breastfeeding at recommended doses.

Paracetamol is a relatively inexpensive and widely available drug with a high safety margin. It is often used as a first-line drug for pain relief and fever reduction, especially in low-resource settings. Studies have shown that paracetamol can provide significant relief of pain and fever symptoms and can improve the quality of life of patients with different types of ailments.

What are the Side Effects of Paracetamol?

In general, paracetamol is safe when used at recommended doses. However, if taken in excessive amounts or for a prolonged period, paracetamol can cause liver damage, particularly in patients with pre-existing liver disease or those who consume alcohol regularly. Prolonged use of paracetamol has also been associated with kidney damage and gastrointestinal ulceration. Other side effects of paracetamol are rare and may include rash, hives, and difficulty breathing.

Paracetamol API Price

The price of paracetamol Active Pharmaceutical Ingredient (API) varies depending on the location, supplier, and demand. In 2023, the average price of paracetamol API is $4.50-$5.50 per kilogram. The cost of paracetamol API in China may be slightly lower due to the presence of many manufacturing facilities and a more competitive market. Paracetalmol suppliers at PharmaSources

Paracetamol API Manufacturers in China

China is the largest producer and exporter of paracetamol API in the world. Some of the leading paracetamol API manufacturers in China include Anhui BBCA Pharmaceutical, Hubei Jusheng Technology Co., Ltd, Zhejiang Kangle Pharmaceutical Co., Ltd, and Jinan Haohua Industry Co., Ltd. These companies have established quality systems and comply with international and local regulations. Paracetalmol suppliers at PharmaSources

Where to Buy Paracetamol API?

Paracetamol API is available from several sources worldwide. Buyers can purchase paracetamol API directly from manufacturers, distributors, or traders. Some of the reputable sources for paracetamol API include Alibaba, Made-in-China, Pharmacompass, and Chemnet. It is essential to conduct thorough due diligence when selecting a supplier to ensure that the product meets the required specifications and standards.

Conclusion

Paracetamol is a widely used pain reliever and fever reducer with a good safety profile. It is available in different forms and formulations, and its mechanism of action makes it an effective drug for the management of mild to moderate pain and fever. While paracetamol is generally safe, it can cause liver and kidney damage if taken in excessive amounts.