99% up, USP32 TRAVOPROST 157283-68-6

Category:Active Pharmaceutical Ingredients > Prostaglandins
Product Name:99% up, USP32 TRAVOPROST 157283-68-6
CAS No.:157283-68-6
Standard:USP, EP, In-house Standards
Price(USD):Negotiable
Company:Sinoway Industrial Co.Ltd.

Basic Info
  • Grade: Pharmaceutical Grade

    Factory Location: Xiamen, Fujian

    Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East

  • Monthly Production Capacity: 100kg

    Packaging Information: 1kg/bottle

  • Sample Provided: yes

    Payment Terms: L/L

     

    Product Information

     

    Product name

    Travoprost

    Molecular Formula

    C26H35F3O6

    Molecular Weight

    500.55

    CAS No.

    157283-68-6

    Quality Standard

    96% up, USP32

    Appearance

    Colorless oil

     

    COA of Travoporst

     

    Tests

    Specifications

    Results

    Description

    A pale yellow to colorless oil

    A colorless oil

    Identification

    TLC; HPLC

    Complies

    Specific Rotation

    +52°~+58°

    +53.15°

    Water

    ≤1.0%

    0.30%

    Related compunds

    Epoxide derivative 1)≤0.4%

    Not detectable

    15-epi Diastereomer 2)≤0.1%

    0.03%

    5,6-trans Isomer 3)≤3.5%

    0.26%

    15-Keto derivative 4)≤0.3%

    0.06%

    Any other impurity ≤0.1%

    0.03%

    Total other impurities ≤1.0%

    0.06%

    Residue Solvent

    Isopropanol≤0.5%

    Not detectable

    Ethyl acetate≤0.25%

    Not detectable

    N-Hexane ≤0.029%

    Not detectable

    Ethanol≤0.5%

    0.33%

    Purity by HPLC

    96.0%~102%

    99.59%

     

    Usage

     

    Function of Travoprost
    Glaucoma is a serious eye disease that threatens human health. It is a blinding eye disease that seriously threatens human visual function. It is the second most blind factor in the world. Its main features are increased intraocular pressure, optic nerve damage, decreased vision and visual field. Shrinkage, severe cases and even vision loss. At present, there is no direct treatment for glaucoma optic neuropathy. The main treatment is to control intraocular pressure and prevent further damage to the optic nerve function. Glaucoma local ocular pressure-lowering drugs have been focusing on the study of inhibiting the production of ciliary body aqueous humor and promoting the outflow of trabecular meshwork water. The drugs for treating glaucoma are mainly eye drops, including β-blockers and pseudo-sympathetic drugs. , Carbonic anhydrase inhibitors, α-receptor agonists, and prostaglandin (PG) analogs. PGs are a class of unsaturated 20-carbon Chemicalbook fatty acids derived from arachidonic acid. PGs, especially PGF2α, are currently considered to be the most promising and effective ocular local pressure reducing drugs. PG analogues such as PGF2α reduce the intraocular pressure by activating PGFP receptors. The combination of these drugs and the PGFP receptor initiates a series of biochemical reactions, opening the uveal sclera drainage pathway, increasing the outflow of aqueous humor, and thereby reducing intraocular pressure. PG analogs, especially PGFP receptor agonists, are a class of approved and effective new drugs for lowering intraocular pressure. Due to the good effect of lowering intraocular pressure, fewer adverse reactions, and fewer times of medication, they have become the main clinical eye drop Press drugs.

    Travoprost is a new type of PG drugs, is an analogue of PGF2α, has a high selectivity and affinity for PGFP receptors, is a complete agonist, is by the US Food and Drug Administration (FDA) A PG drug approved in September 2006 for the treatment of primary open-angle glaucoma and ocular hypertension. The molecular structure of travoprost contains a pentene ring with α- and ω-carbon chains. The esters at the end of the α-chain help penetrate the cornea and decompose into free acids in the stroma of the cornea. FP receptors combine to reduce intraocular pressure by increasing the outflow of aqueous humor through the uveal scleral pathway.

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