Cefotaxime Sodium for Injection

Strength: 1.0g/vial;1.5g/vial;2.0g/vial;3.0g/vial.

Cefotaxime is an antibiotic used to treat a number of bacterial infections. Specifically it is used to treat joint infections, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, sepsis, gonorrhea, andcellulitis.

It is a broad-spectrum antibiotic with activity against numerous gram-positive and gram-negative bacteria.

Given its broad spectrum of activity, cefotaxime is used for a variety of infections, including:

• Lower respiratory tract infections - e.g. pneumonia (most commonly caused by S. pneumoniae)
• Genitourinary system infections - urinary tract infections (e.g. E. coli, S. epidermidis, P. mirabilis) and cervical/urethral gonorrhea
• Gynecologic infections - e.g. pelvic inflammatory disease, endometritis, and pelvic cellulitis
• Bacteremia/septicemia - secondary to Streptococcus spp., S. aureus, E. coli, and Klebsiella spp.
• Intra-abdominal infections - e.g. peritonitis
• Bone and join infections - S. aureus, Streptococcus spp.
• CNS infections - e.g. meningitis/ventriculitis secondary to N. meningitidis, H. influenzae, S. pneumoniae

Although cefotaxime has demonstrated efficacy in these infections, it is not necessarily considered to be the first-line agent. In meningitis, cefotaxime crosses the blood–brain barrier better than cefuroxime.