Idebenone Powder

What Is Idebenone?

The chemical name of idebenone powder is 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methylbenzoquinone. It has an activating effect on the thread-pulling function and has a positive effect on brain function metabolism and brain function. It has the effect of improving disorders, improving the utilization rate of glucose in the brain, promoting the generation of ATP; improving the metabolism of the neurotransmitter 5-hydroxytryptamine in the brain, and has strong antioxidant and free radical scavenging effects. It is mainly used clinically to treat many degenerative diseases of the central nervous system related to oxidative stress, such as Parkinson's disease, Alzheimer's disease, multi-infarct dementia, cerebral anemia and brain failure. It is also used in Friedrich's disease. In the treatment of ataxia, it can also be used in cosmetic formulas, with cosmetic functions such as scavenging free radicals, inhibiting lipid peroxidation, inhibiting inflammation, inhibiting DNA damage, photoprotection, and reducing pigmentation.
Idebenone is an organic compound with the molecular formula C19H30O5. It is yellow crystal or crystalline powder and odorless. It is extremely difficult to dissolve in water, very soluble in chloroform, methanol or absolute ethanol, easily soluble in ethyl acetate, and difficult to dissolve in n-hexane. Used in cosmetic formulations.

Principle Of Action:

Idebenone is an analogue of coenzyme Q10. Coenzyme Q is a fat-soluble quinone compound widely present in organisms. It has the function of promoting oxidative phosphorylation reactions and protecting the structural integrity of biological membranes. Coenzyme Q from different sources has different numbers of isopentenyl units in its side chain. Humans and mammals have 10 isopentenyl units, so it is called coenzyme Q10. Coenzyme Q plays an important role in proton translocation and electron transfer in the respiratory chain in the body. It is an activator of cellular respiration and cell metabolism, and is also an important antioxidant and non-specific immune enhancer.

What Are The Benefits?

1. Excellent Free Radical Scavenger
Idebenone powder has strong free scavenging ability among several common antioxidants. At the same concentration, it has the same ability to scavenge DPPH and AAPH as water-soluble vitamin E, and its ability to scavenge ABTS free radicals, tyrosine free radicals and peroxynitrite anions is 50% of water-soluble vitamin E. Idebenone, ascorbic acid and vitamin E can effectively eliminate free radicals at lower concentrations (10nmol/L). Coenzyme Q10 and kinetin need to be at concentrations of 100nmol/L and 1000nmol/L respectively to show their ability to scavenge free radicals.

2. Inhibit Lipid Peroxidation
Compared with ascorbic acid (>20mol/L), a-tocopherol (100rtmol/L), and glutathione (50tzmol/L), low concentration of idebenone (10Fmol/L) showed stronger antioxidant It can effectively inhibit the formation of lipid peroxides.

3. Inhibit Inflammation And Repair Cutin
The Caspase (caspase) family is an inflammatory process and plays a very important role in mediating apoptosis, of which Caspase-3 is an important one. In the experiment, 0.5t,mol/L diethyl maleate and 0.1Fmol/L hydrogen peroxide were used to activate Caspase-3 respectively, thus reflecting the degree of cell apoptosis. Studies have shown that 0.5~mol/L idebenone can significantly reduce the degree of apoptosis induced by diethyl maleate and hydrogen peroxide, thereby inhibiting the occurrence of inflammation and improving tissue repair capabilities.

4. Prevent And Treat DNA Damage
Studies have shown that with sufficient UVB irradiation, the production of photoproducts in keratinocytes without any antioxidants is 53%, the production of photoproducts with idebenone is 23%, and the photoinhibition rate is 43%, while vitamin C, agonist The photoproduct inhibition rates of coenzyme, coenzyme Q10 and alpha-lipoic acid were 36%, 36%, 4% and 0% respectively. Significantly reduces UVB damage to DNA. ​

5. Inhibit Light Damage
The study found that when UVB was used to irradiate skin that had been coated with antioxidants, the sunburn cells of the skin coated with 0.5 idebenone were reduced by 38% compared to the blank, while vitamin E, kinetin, coenzyme Q10 and alpha-lipoic acid were respectively Reductions of 30%, 20%, 10%, 9% and 0%. It can be seen that idebenone has the most significant effect in inhibiting photodamage. ​

6. Inhibit Melanin Production
The inhibitory effect on melanin is positively correlated with the amount added. High concentrations of idebenone and hydroquinone have similar effects; after a certain dilution, the inhibitory effect of hydroquinone on melanin disappears, while low concentrations of idebenone still show inhibitory effects.

Application Direction

The history of idebenone's use in medicine can be traced back to 1982. The paper originally published by Shimamoto et al. introduced its potential application in the scientific community, which mentioned its role in the energy metabolism of red blood cells and myocardial tissue. effect. Over the next few years, further studies determined the tolerability, safety, and pharmacokinetics of idebenone, marking the first phase of idebenone's use. In the early 1990s, idebenone was used in patients with Alzheimer's disease. Since then, it has been more extensively studied and applied to the treatment of other age-related diseases, including cerebrovascular disease, Alzheimer's disease, etc., and has also been used in other applications such as organ preservation.
Potential benefits of idebenone include: anti-aging, energy enhancement, cognitive enhancement, organ protection, and anti-excitatory amino acid neurotoxicity. In 2003, idebenone was introduced into the field of dermatology as a novel compound to treat acute and chronic skin aging.
It is also widely used in the field of cosmetics

Company Introduction And Certificates Obtained

Founded in 2014, YTBIO mainly supplies food additives such as Idebenone Powder, herbal extracts, functional cosmetic raw materials, organic products, etc. All of our products are produced by ourselves. At present, our certificates include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA, etc. All our products have been tested and we support third-party testing. We provide a variety of products, for any detailed information about the products, please click Sales@Sxytbio.Com Contact us, we will have professional sales staff to give you detailed answers