SALINOMYCIN

• Chemical abstract service (CAS) registry number: 55721-31-8
• Molecular formula: C₄₂H₆₉NaO₁₁
• Molecular Weight: 722.98
• Loss on drying: Not more than 8.0%.
• Heavy metals: Not more than 20ppm.
• Arsenic: Not more than 2ppm.
• Salinomycin A: Content of Salinomycin A should be more than 85.0%.
• Related substances

  Any individual impurity should be not more than 5.0%, total impurities should be not more than 10.0%.

• Assay: Should be 90.0%~110.0% of the labeled amount.
• Efficacy

    Salinomycin is a polyether antibiotic from the group of ionophores. It exerts anticoccidial effect against all species known as causative agents of coccidiosis in poultry (Eimeria acervulina, E.maxima, E.necatrix,E.mivata, E.tenella, E.brunetti) as well as in the other farm animals (E.meleagridis, E.meleagrimitis, E.bovis,etc.). It is active against Gram-positive microorganisms, some anaerobes and Serpulina (Treponema) hyodysenteriae. The biological activity of salinomycin is based on its ability to form lipophilic complexes with the monovalent alkaline ions, making the cellular membranes of coccidia permeable to the ions mentioned. In this way, the intracellular ion concentration in the parasite cells is disturbed and anticoccidial effect of the preparation is achieved. This action is manifested already at the earliest stage of coccidia development hindering the maturity of the schizonts and the development of merozoites. An additional influence is the impeded transport of carbohydrate and the active sporozoite glycolysis provoked by salinomycin. The administration of salinomycin with the feed to ruminants (with developed fore-stomachs) at the recommended concentrations improves the weight gain and the feed conversion efficiency of the animals (as a result of the influence on the microflora and microfauna in the fore-stomachs which leads to an increase in the concentration of propionic acid and a decrease in the concentrations of lactic acid and acetic acid and a diminution of methane eructation from the rumen).Salinomycin reveals a nutritive effect in the growing and fattening pigs as well (affecting positively the beneficial microflora in the digestive tract of the animals).

• Indications

    For prevention and treatment of Coccidiosis.

• Usage and Dosage

    Mix with feed: Chicken: 60g as activity per 1000kgs feed.

• Withdrawal period: 5 days.
• Storage: Tightly sealed and store in a dry place at room temperature.
• Shelf life: 2 years.
• Content: 12%, 24%