Notes on the Use of Sulfonamides Drugs

Sulfonamide drugs have been used clinically for decades. They have a broad antibacterial spectrum, definite curative effect, stable properties, easy use, low price, and easy long-term storage. Therefore, they are still second only to antibiotics. After the synthesis of high-efficiency, long-acting and broad-spectrum sulfonamide drugs and antibacterial synergists, the clinical application of sulfonamide drugs has a new and broad prospect.

1. Choose different types of sulfonamide drugs according to the nature of the disease

Systemic infectious diseases: such as sepsis, drugs that are easily absorbed by the intestines, such as cotrimoxazole and sulfadiazine, should be used. Intestinal infections: such as enteritis and diarrheal diseases, drugs that are not easily absorbed by the intestines, such as sulfamidine, should be used. Local infection: such as burns, topical sulfa drugs should be used, such as anti-inflammatory powder, burn ning, etc. Parasitic infection: such as coccidia and leukocyte protozoa infection, sulfamethazine should be used. If you are looking for different types of sulfonamides, Pharmasources would be a great platform for you.

2. Determine the medication time and dosage according to the nature of sulfonamide drugs

The dosage of sulfonamide drugs is divided into shock dosage and maintenance dosage. All surprise doses, that is, the first or first day doses are doubled within the safe range, and then changed to maintenance doses, that is, the combined application of normal doses of sulfa drugs and the combined use of baking soda (sodium bicarbonate). Sulfonamide drugs are easy to crystallize in an acidic environment. If sulfonamide drugs are used alone, when they are excreted by the kidneys, sulfonamide crystals are easy to precipitate and block the ureter. Therefore, it should be used in combination with baking soda to prevent crystals from appearing. In addition, sulfonamide drugs should be used with caution or disabled when renal function declines and systemic acidosis occurs.

Pay attention to the use period of sulfonamide drugs to prevent accumulation of poisoning. Sulfonamide drugs require accurate and uniform doses when used, and the course of treatment is 3 to 5 days, and should not exceed 7 days. Because long-term high-dose use can easily lead to accumulation of poisoning.

3. Precautions for the use of sulfonamide drugs

Such drugs should not be used for 3 days before and after the vaccine is used, because sulfonamide drugs can inhibit the activity of antigens and reduce the immune effect. The substance contains a large amount of para-aminobenzoic acid, which affects the efficacy of sulfa drugs. Sulfonamide drugs have the effect of causing deformed fetuses, so they are contraindicated in late pregnancy.

The use of sulfonamide drugs should strictly control the dose, and the medication should not exceed 7 days, and at the same time add sufficient water. Use sulfa compound preparations to reduce the dosage and avoid poisoning. Stir the ingredients evenly. Once sulfa drug poisoning occurs, stop the drug immediately. Supply enough drinking water. You can take 1% to 3% sodium bicarbonate solution at the same time. Add in the feed Vitamin C and vitamin K; use renal antidote in case of poisoning.